Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1).
Bachovchin DA, Speers AE, Brown SJ, Spicer TP, Fernandez-Vega V, Ferguson J, Mohr JT, Murphy J, Fu GC, Cravatt BF, Hodder PS, Rosen H.
Bachovchin DA, et al. Among authors: speers ae.
2010 Aug 31 [updated 2011 Dec 12]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.
2010 Aug 31 [updated 2011 Dec 12]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.
PMID: 22834039
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Adding further complexity, several residues of the catalytic subunit of PP2A can be reversibly phosphorylated, and the C-terminal leucine residue can be reversibly methylated. Protein phosphatase methylesterase-1 (PME-1) is specifically responsible for demethylation of the …
Adding further complexity, several residues of the catalytic subunit of PP2A can be reversibly phosphorylated, and the C-terminal leu …