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Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.
Biochem Soc Trans. 2015 Aug;43(4):611-20. doi: 10.1042/BST20150011. Epub 2015 Aug 3.
Biochem Soc Trans. 2015.
PMID: 26551701
Review.
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease.
Tebay LE, Robertson H, Durant ST, Vitale SR, Penning TM, Dinkova-Kostova AT, Hayes JD.
Tebay LE, et al.
Free Radic Biol Med. 2015 Nov;88(Pt B):108-146. doi: 10.1016/j.freeradbiomed.2015.06.021. Epub 2015 Jun 27.
Free Radic Biol Med. 2015.
PMID: 26122708
Free PMC article.
Review.
Item in Clipboard
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.
Hayes JD, Dinkova-Kostova AT.
Hayes JD, et al.
Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
Trends Biochem Sci. 2014.
PMID: 24647116
Review.
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Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.
Chowdhry S, Zhang Y, McMahon M, Sutherland C, Cuadrado A, Hayes JD.
Chowdhry S, et al.
Oncogene. 2013 Aug 8;32(32):3765-81. doi: 10.1038/onc.2012.388. Epub 2012 Sep 10.
Oncogene. 2013.
PMID: 22964642
Free PMC article.
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