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The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models.
Cancer Lett. 2020 Mar 31;473:186-197. doi: 10.1016/j.canlet.2019.09.009. Epub 2019 Sep 24.
Cancer Lett. 2020.
PMID: 31560935
Free article.
Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment.
Deshmukh V, O'Green AL, Bossard C, Seo T, Lamangan L, Ibanez M, Ghias A, Lai C, Do L, Cho S, Cahiwat J, Chiu K, Pedraza M, Anderson S, Harris R, Dellamary L, Kc S, Barroga C, Melchior B, Tam B, Kennedy S, Tambiah J, Hood J, Yazici Y.
Deshmukh V, et al. Among authors: cahiwat j.
Osteoarthritis Cartilage. 2019 Sep;27(9):1347-1360. doi: 10.1016/j.joca.2019.05.006. Epub 2019 May 25.
Osteoarthritis Cartilage. 2019.
PMID: 31132406
Free article.
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A small-molecule inhibitor of the Wnt pathway, lorecivivint (SM04690), as a potential disease-modifying agent for the treatment of degenerative disc disease.
Deshmukh V, Ibanez M, Hu H, Cahiwat J, Wei Y, Stewart J, Hood J, Yazici Y.
Deshmukh V, et al. Among authors: cahiwat j.
Spine J. 2020 Sep;20(9):1492-1502. doi: 10.1016/j.spinee.2020.04.024. Epub 2020 May 12.
Spine J. 2020.
PMID: 32413487
Free article.
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A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee.
Deshmukh V, Hu H, Barroga C, Bossard C, Kc S, Dellamary L, Stewart J, Chiu K, Ibanez M, Pedraza M, Seo T, Do L, Cho S, Cahiwat J, Tam B, Tambiah JRS, Hood J, Lane NE, Yazici Y.
Deshmukh V, et al. Among authors: cahiwat j.
Osteoarthritis Cartilage. 2018 Jan;26(1):18-27. doi: 10.1016/j.joca.2017.08.015. Epub 2017 Sep 6.
Osteoarthritis Cartilage. 2018.
PMID: 28888902
Free article.
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