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Oxidation of indole by cytochrome P450 enzymes.
Gillam EM, Notley LM, Cai H, De Voss JJ, Guengerich FP. Gillam EM, et al. Among authors: cai h. Biochemistry. 2000 Nov 14;39(45):13817-24. doi: 10.1021/bi001229u. Biochemistry. 2000. PMID: 11076521
Reaction of trichloroethylene and trichloroethylene oxide with cytochrome P450 enzymes: inactivation and sites of modification.
Cai H, Guengerich FP. Cai H, et al. Chem Res Toxicol. 2001 Apr;14(4):451-8. doi: 10.1021/tx0002280. Chem Res Toxicol. 2001. PMID: 11304134
TCE oxide is a reactive electrophile formed during TCE oxidation and rearranges to acylating intermediates [Cai, H., and Guengerich, F. P. (1999) J. Am. Chem. Soc. 121, 11656-11663], which may be related to the toxicity. ...
TCE oxide is a reactive electrophile formed during TCE oxidation and rearranges to acylating intermediates [Cai, H., and Gueng …
Reaction of trichloroethylene oxide with proteins and dna: instability of adducts and modulation of functions.
Cai H, Guengerich FP. Cai H, et al. Chem Res Toxicol. 2001 Jan;14(1):54-61. doi: 10.1021/tx000185n. Chem Res Toxicol. 2001. PMID: 11170508
We previously analyzed N(6)-acyllysine adducts formed from the reaction of TCE oxide with proteins [Cai, H., and Guengerich, F. P. (2000) Chem. Res. Toxicol. 13, 327-335]; however, we had been unable to measure ester adducts under the prolonged conditions of proteol …
We previously analyzed N(6)-acyllysine adducts formed from the reaction of TCE oxide with proteins [Cai, H., and Guengerich, F …
8,188 results