Cain SA - Search Results

1

Characterisation of C5a receptor agonists from phage display libraries.

Cain SA, Higginbottom A, Monk PN. Cain SA, et al. Biochem Pharmacol. 2003 Nov 1;66(9):1833-40. doi: 10.1016/s0006-2952(03)00473-8. Biochem Pharmacol. 2003. PMID: 14563493

2

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).

Cain SA, Monk PN. Cain SA, et al. J Biol Chem. 2002 Mar 1;277(9):7165-9. doi: 10.1074/jbc.C100714200. Epub 2001 Dec 31. J Biol Chem. 2002. PMID: 11773063 Free article.

3

Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.

Higginbottom A, Cain SA, Woodruff TM, Proctor LM, Madala PK, Tyndall JD, Taylor SM, Fairlie DP, Monk PN. Higginbottom A, et al. Among authors: cain sa. J Biol Chem. 2005 May 6;280(18):17831-40. doi: 10.1074/jbc.M410797200. Epub 2005 Jan 20. J Biol Chem. 2005. PMID: 15661745 Free article.

4

Mapping the ligand-binding site on the C5a receptor: arginine74 of C5a contacts aspartate282 of the C5a receptor.

Cain SA, Coughlan T, Monk PN. Cain SA, et al. Biochemistry. 2001 Nov 20;40(46):14047-52. doi: 10.1021/bi011055w. Biochemistry. 2001. PMID: 11705397

5

Analysis of receptor/ligand interactions using whole-molecule randomly-mutated ligand libraries.

Cain SA, Ratcliffe CF, Williams DM, Harris V, Monk PN. Cain SA, et al. J Immunol Methods. 2000 Nov 1;245(1-2):139-45. doi: 10.1016/s0022-1759(00)00282-9. J Immunol Methods. 2000. PMID: 11042291

6

Selection of novel ligands from a whole-molecule randomly mutated C5a library.

Cain SA, Williams DM, Harris V, Monk PN. Cain SA, et al. Protein Eng. 2001 Mar;14(3):189-93. doi: 10.1093/protein/14.3.189. Protein Eng. 2001. PMID: 11342716

7

Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor.

Cain SA, Woodruff TM, Taylor SM, Fairlie DP, Sanderson SD, Monk PN. Cain SA, et al. Biochem Pharmacol. 2001 Jun 15;61(12):1571-9. doi: 10.1016/s0006-2952(01)00608-6. Biochem Pharmacol. 2001. PMID: 11377387

8

Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand.

Crass T, Bautsch W, Cain SA, Pease JE, Monk PN. Crass T, et al. Among authors: cain sa. Biochemistry. 1999 Jul 27;38(30):9712-7. doi: 10.1021/bi990139q. Biochemistry. 1999. PMID: 10423250

9

Pharmacological characterization of antagonists of the C5a receptor.

Paczkowski NJ, Finch AM, Whitmore JB, Short AJ, Wong AK, Monk PN, Cain SA, Fairlie DP, Taylor SM. Paczkowski NJ, et al. Among authors: cain sa. Br J Pharmacol. 1999 Dec;128(7):1461-6. doi: 10.1038/sj.bjp.0702938. Br J Pharmacol. 1999. PMID: 10602324 Free PMC article.

10

The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.

Kalant D, Cain SA, Maslowska M, Sniderman AD, Cianflone K, Monk PN. Kalant D, et al. Among authors: cain sa. J Biol Chem. 2003 Mar 28;278(13):11123-9. doi: 10.1074/jbc.M206169200. Epub 2003 Jan 22. J Biol Chem. 2003. PMID: 12540846 Free article.

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