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A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor.
Montembault M, Vo-Thanh G, Deyine A, Fargeas V, Villiéras M, Adjou A, Dubreuil D, Esquieu D, Grégoire C, Opi S, Péloponèse JM, Campbell G, Watkins J, de Mareuil J, Aubertin AM, Bailly C, Loret E, Lebreton J. Montembault M, et al. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1543-6. doi: 10.1016/j.bmcl.2003.12.095. Bioorg Med Chem Lett. 2004. PMID: 15006399
Full-length HIV-1 Tat protein necessary for a vaccine.
Opi S, Péloponèse JM Jr, Esquieu D, Watkins J, Campbell G, De Mareuil J, Jeang KT, Yirrell DL, Kaleebu P, Loret EP. Opi S, et al. Vaccine. 2004 Aug 13;22(23-24):3105-11. doi: 10.1016/j.vaccine.2004.01.057. Vaccine. 2004. PMID: 15297062
The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis.
Campbell GR, Pasquier E, Watkins J, Bourgarel-Rey V, Peyrot V, Esquieu D, Barbier P, de Mareuil J, Braguer D, Kaleebu P, Yirrell DL, Loret EP. Campbell GR, et al. J Biol Chem. 2004 Nov 12;279(46):48197-204. doi: 10.1074/jbc.M406195200. Epub 2004 Aug 24. J Biol Chem. 2004. PMID: 15331610 Free article.
HIV-1 Tat protein enhances microtubule polymerization.
de Mareuil J, Carre M, Barbier P, Campbell GR, Lancelot S, Opi S, Esquieu D, Watkins JD, Prevot C, Braguer D, Peyrot V, Loret EP. de Mareuil J, et al. Among authors: campbell gr. Retrovirology. 2005 Feb 3;2:5. doi: 10.1186/1742-4690-2-5. Retrovirology. 2005. PMID: 15691386 Free PMC article.
258 results