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Tumour hypoxia causes DNA hypermethylation by reducing TET activity.
Thienpont B, Steinbacher J, Zhao H, D'Anna F, Kuchnio A, Ploumakis A, Ghesquière B, Van Dyck L, Boeckx B, Schoonjans L, Hermans E, Amant F, Kristensen VN, Peng Koh K, Mazzone M, Coleman M, Carell T, Carmeliet P, Lambrechts D. Thienpont B, et al. Among authors: carell t. Nature. 2016 Sep 1;537(7618):63-68. doi: 10.1038/nature19081. Epub 2016 Aug 17. Nature. 2016. PMID: 27533040 Free PMC article.
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
Pfaffeneder T, Spada F, Wagner M, Brandmayr C, Laube SK, Eisen D, Truss M, Steinbacher J, Hackner B, Kotljarova O, Schuermann D, Michalakis S, Kosmatchev O, Schiesser S, Steigenberger B, Raddaoui N, Kashiwazaki G, Müller U, Spruijt CG, Vermeulen M, Leonhardt H, Schär P, Müller M, Carell T. Pfaffeneder T, et al. Among authors: carell t. Nat Chem Biol. 2014 Jul;10(7):574-81. doi: 10.1038/nchembio.1532. Epub 2014 May 18. Nat Chem Biol. 2014. PMID: 24838012
Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.
Gassen NC, Fries GR, Zannas AS, Hartmann J, Zschocke J, Hafner K, Carrillo-Roa T, Steinbacher J, Preißinger SN, Hoeijmakers L, Knop M, Weber F, Kloiber S, Lucae S, Chrousos GP, Carell T, Ising M, Binder EB, Schmidt MV, Rüegg J, Rein T. Gassen NC, et al. Among authors: carell t. Sci Signal. 2015 Nov 24;8(404):ra119. doi: 10.1126/scisignal.aac7695. Sci Signal. 2015. PMID: 26602018
Active DNA demethylation at enhancers during the vertebrate phylotypic period.
Bogdanović O, Smits AH, de la Calle Mustienes E, Tena JJ, Ford E, Williams R, Senanayake U, Schultz MD, Hontelez S, van Kruijsbergen I, Rayon T, Gnerlich F, Carell T, Veenstra GJ, Manzanares M, Sauka-Spengler T, Ecker JR, Vermeulen M, Gómez-Skarmeta JL, Lister R. Bogdanović O, et al. Among authors: carell t. Nat Genet. 2016 Apr;48(4):417-26. doi: 10.1038/ng.3522. Epub 2016 Feb 29. Nat Genet. 2016. PMID: 26928226 Free PMC article.
5-Formylcytosine to cytosine conversion by C-C bond cleavage in vivo.
Iwan K, Rahimoff R, Kirchner A, Spada F, Schröder AS, Kosmatchev O, Ferizaj S, Steinbacher J, Parsa E, Müller M, Carell T. Iwan K, et al. Among authors: carell t. Nat Chem Biol. 2018 Jan;14(1):72-78. doi: 10.1038/nchembio.2531. Epub 2017 Nov 27. Nat Chem Biol. 2018. PMID: 29176672
299 results