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Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids.
Stöhr D, Schmid JO, Beigl TB, Mack A, Maichl DS, Cao K, Budai B, Fullstone G, Kontermann RE, Mürdter TE, Tait SWG, Hagenlocher C, Pollak N, Scheurich P, Rehm M. Stöhr D, et al. Among authors: hagenlocher c. Cell Death Differ. 2020 Nov;27(11):3037-3052. doi: 10.1038/s41418-020-0559-3. Epub 2020 May 20. Cell Death Differ. 2020. PMID: 32433558 Free PMC article.
Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol.
Hellwig CT, Delgado ME, Skoko J, Dyck L, Hanna C, Wentges A, Langlais C, Hagenlocher C, Mack A, Dinsdale D, Cain K, MacFarlane M, Rehm M. Hellwig CT, et al. Among authors: hagenlocher c. Cell Death Differ. 2022 Jan;29(1):147-155. doi: 10.1038/s41418-021-00843-7. Epub 2021 Aug 5. Cell Death Differ. 2022. PMID: 34354257 Free PMC article.