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Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV Jr, Kukar T, Tansey MG. Chen X, et al. Among authors: cenik b. J Neurosci. 2013 May 22;33(21):9202-13. doi: 10.1523/JNEUROSCI.5336-12.2013. J Neurosci. 2013. PMID: 23699531 Free PMC article.
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV Jr, Posner BA, Yu G, Herz J. Cenik B, et al. J Biol Chem. 2011 May 6;286(18):16101-8. doi: 10.1074/jbc.M110.193433. Epub 2011 Mar 23. J Biol Chem. 2011. PMID: 21454553 Free PMC article.
Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency.
Evers BM, Rodriguez-Navas C, Tesla RJ, Prange-Kiel J, Wasser CR, Yoo KS, McDonald J, Cenik B, Ravenscroft TA, Plattner F, Rademakers R, Yu G, White CL 3rd, Herz J. Evers BM, et al. Among authors: cenik b. Cell Rep. 2017 Sep 12;20(11):2565-2574. doi: 10.1016/j.celrep.2017.08.056. Cell Rep. 2017. PMID: 28903038 Free PMC article.
Prosaposin is a regulator of progranulin levels and oligomerization.
Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, Fuchsberger C, Fowler S, Teslovich TM, Manning AK, Kumar S, Curran J, Lehman D, Abecasis G, Duggirala R, Pottier C, Zahir HA, Crook JE, Karydas A, Mitic L, Sun Y, Dickson DW, Bu G, Herz J, Yu G, Miller BL, Ferguson S, Petersen RC, Graff-Radford N, Blangero J, Rademakers R. Nicholson AM, et al. Among authors: cenik b. Nat Commun. 2016 Jun 30;7:11992. doi: 10.1038/ncomms11992. Nat Commun. 2016. PMID: 27356620 Free PMC article.
TDP-43 aggregation in neurodegeneration: are stress granules the key?
Dewey CM, Cenik B, Sephton CF, Johnson BA, Herz J, Yu G. Dewey CM, et al. Among authors: cenik b. Brain Res. 2012 Jun 26;1462:16-25. doi: 10.1016/j.brainres.2012.02.032. Epub 2012 Feb 22. Brain Res. 2012. PMID: 22405725 Free PMC article. Review.
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