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A highly efficacious live attenuated mumps virus-based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike.
Zhang Y, Lu M, Mahesh KC, Kim E, Shamseldin MM, Ye C, Dravid P, Chamblee M, Park JG, Hall JM, Trivedi S, Chaiwatpongsakorn S, Kenny AD, Murthy SS, Sharma H, Liang X, Yount JS, Kapoor A, Martinez-Sobrido L, Dubey P, Boyaka PN, Peeples ME, Li J. Zhang Y, et al. Among authors: chaiwatpongsakorn s. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2201616119. doi: 10.1073/pnas.2201616119. Epub 2022 Jul 27. Proc Natl Acad Sci U S A. 2022. PMID: 35895717 Free PMC article.
A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike.
Lu M, Dravid P, Zhang Y, Trivedi S, Li A, Harder O, Kc M, Chaiwatpongsakorn S, Zani A, Kenney A, Zeng C, Cai C, Ye C, Liang X, Shimamura M, Liu SL, Mejias A, Ramilo O, Boyaka PN, Qiu J, Martinez-Sobrido L, Yount JS, Peeples ME, Kapoor A, Niewiesk S, Li J. Lu M, et al. Among authors: chaiwatpongsakorn s. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2026153118. doi: 10.1073/pnas.2026153118. Proc Natl Acad Sci U S A. 2021. PMID: 33688034 Free PMC article.
SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern.
Lu M, Chamblee M, Zhang Y, Ye C, Dravid P, Park JG, Mahesh KC, Trivedi S, Murthy S, Sharma H, Cassady C, Chaiwatpongsakorn S, Liang X, Yount JS, Boyaka PN, Peeples ME, Martinez-Sobrido L, Kapoor A, Li J. Lu M, et al. Among authors: chaiwatpongsakorn s. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2110105119. doi: 10.1073/pnas.2110105119. Epub 2022 Aug 22. Proc Natl Acad Sci U S A. 2022. PMID: 35994646 Free PMC article.
A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters.
Lu M, Zhang Y, Dravid P, Li A, Zeng C, Kc M, Trivedi S, Sharma H, Chaiwatpongsakorn S, Zani A, Kenney A, Cai C, Ye C, Liang X, Qiu J, Martinez-Sobrido L, Yount JS, Boyaka PN, Liu SL, Peeples ME, Kapoor A, Li J. Lu M, et al. Among authors: chaiwatpongsakorn s. J Virol. 2021 Sep 27;95(20):e0059221. doi: 10.1128/JVI.00592-21. Epub 2021 Aug 11. J Virol. 2021. PMID: 34379509 Free PMC article.
Targeting RSV with vaccines and small molecule drugs.
Costello HM, Ray WC, Chaiwatpongsakorn S, Peeples ME. Costello HM, et al. Among authors: chaiwatpongsakorn s. Infect Disord Drug Targets. 2012 Apr;12(2):110-28. doi: 10.2174/187152612800100143. Infect Disord Drug Targets. 2012. PMID: 22335496 Free PMC article. Review.
Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Battles MB, Langedijk JP, Furmanova-Hollenstein P, Chaiwatpongsakorn S, Costello HM, Kwanten L, Vranckx L, Vink P, Jaensch S, Jonckers TH, Koul A, Arnoult E, Peeples ME, Roymans D, McLellan JS. Battles MB, et al. Among authors: chaiwatpongsakorn s. Nat Chem Biol. 2016 Feb;12(2):87-93. doi: 10.1038/nchembio.1982. Epub 2015 Dec 7. Nat Chem Biol. 2016. PMID: 26641933 Free PMC article.
Prime-Pull Immunization of Mice with a BcfA-Adjuvanted Vaccine Elicits Sustained Mucosal Immunity That Prevents SARS-CoV-2 Infection and Pathology.
Shamseldin MM, Kenney A, Zani A, Evans JP, Zeng C, Read KA, Hall JM, Chaiwatpongsakorn S, Mahesh KC, Lu M, Eltobgy M, Denz P, Deora R, Li J, Peeples ME, Oestreich KJ, Liu SL, Corps KN, Yount JS, Dubey P. Shamseldin MM, et al. Among authors: chaiwatpongsakorn s. J Immunol. 2023 May 1;210(9):1257-1271. doi: 10.4049/jimmunol.2200297. J Immunol. 2023. PMID: 36881867