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Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.
Nakazato A, Kumagai T, Sakagami K, Yoshikawa R, Suzuki Y, Chaki S, Ito H, Taguchi T, Nakanishi S, Okuyama S. Nakazato A, et al. Among authors: chaki s. J Med Chem. 2000 Dec 14;43(25):4893-909. doi: 10.1021/jm000346k. J Med Chem. 2000. PMID: 11123999
Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor.
Chaki S, Hirota S, Funakoshi T, Suzuki Y, Suetake S, Okubo T, Ishii T, Nakazato A, Okuyama S. Chaki S, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):818-26. doi: 10.1124/jpet.102.044826. J Pharmacol Exp Ther. 2003. PMID: 12538838
281 results