Chand P - Search Results

1

BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.

Babu YS, Chand P, Bantia S, Kotian P, Dehghani A, El-Kattan Y, Lin TH, Hutchison TL, Elliott AJ, Parker CD, Ananth SL, Horn LL, Laver GW, Montgomery JA. Babu YS, et al. Among authors: chand p. J Med Chem. 2000 Sep 21;43(19):3482-6. doi: 10.1021/jm0002679. J Med Chem. 2000. PMID: 11000002 No abstract available.

2

Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives.

Chand P, Babu YS, Bantia S, Rowland S, Dehghani A, Kotian PL, Hutchison TL, Ali S, Brouillette W, El-Kattan Y, Lin TH. Chand P, et al. J Med Chem. 2004 Apr 8;47(8):1919-29. doi: 10.1021/jm0303406. J Med Chem. 2004. PMID: 15055992

3

Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase.

Chand P, Kotian PL, Morris PE, Bantia S, Walsh DA, Babu YS. Chand P, et al. Bioorg Med Chem. 2005 Apr 1;13(7):2665-78. doi: 10.1016/j.bmc.2005.01.042. Bioorg Med Chem. 2005. PMID: 15755666

4

Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo.

Chand P, Bantia S, Kotian PL, El-Kattan Y, Lin TH, Babu YS. Chand P, et al. Bioorg Med Chem. 2005 Jun 2;13(12):4071-7. doi: 10.1016/j.bmc.2005.03.048. Epub 2005 Apr 25. Bioorg Med Chem. 2005. PMID: 15911320

5

Probing the S2 site of factor VIIa to generate potent and selective inhibitors: the structure of BCX-3607 in complex with tissue factor-factor VIIa.

Krishnan R, Kotian PL, Chand P, Bantia S, Rowland S, Babu YS. Krishnan R, et al. Among authors: chand p. Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):689-97. doi: 10.1107/S0907444907014187. Epub 2007 May 15. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 17505107

6

Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.

Kotian PL, Krishnan R, Rowland S, El-Kattan Y, Saini SK, Upshaw R, Bantia S, Arnold S, Babu YS, Chand P. Kotian PL, et al. Among authors: chand p. Bioorg Med Chem. 2009 Jun 1;17(11):3934-58. doi: 10.1016/j.bmc.2009.04.013. Epub 2009 Apr 12. Bioorg Med Chem. 2009. PMID: 19409795

7

Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.

Niwas S, Chand P, Pathak VP, Montgomery JA. Niwas S, et al. Among authors: chand p. J Med Chem. 1994 Jul 22;37(15):2477-80. doi: 10.1021/jm00041a027. J Med Chem. 1994. PMID: 8057293

8

Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design.

Chand P, Babu YS, Bantia S, Chu N, Cole LB, Kotian PL, Laver WG, Montgomery JA, Pathak VP, Petty SL, Shrout DP, Walsh DA, Walsh GM. Chand P, et al. J Med Chem. 1997 Dec 5;40(25):4030-52. doi: 10.1021/jm970479e. J Med Chem. 1997. PMID: 9406595

9

Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent.

Atigadda VR, Brouillette WJ, Duarte F, Ali SM, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Sudbeck EA, Finley J, Luo M, Air GM, Laver GW. Atigadda VR, et al. Among authors: chand p. J Med Chem. 1999 Jul 1;42(13):2332-43. doi: 10.1021/jm980707k. J Med Chem. 1999. PMID: 10395473

10

Hydrophobic benzoic acids as inhibitors of influenza neuraminidase.

Atigadda VR, Brouillette WJ, Duarte F, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Sudbeck E, Finley J, Air GM, Luo M, Laver GW. Atigadda VR, et al. Among authors: chand p. Bioorg Med Chem. 1999 Nov;7(11):2487-97. doi: 10.1016/s0968-0896(99)00197-2. Bioorg Med Chem. 1999. PMID: 10632058

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