Chappell A - Search Results

1

Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans.

Shen L, Frazer-Abel A, Reynolds PR, Giclas PC, Chappell A, Pangburn MK, Younis H, Henry SP. Shen L, et al. Among authors: chappell a. J Pharmacol Exp Ther. 2014 Dec;351(3):709-17. doi: 10.1124/jpet.114.219378. Epub 2014 Oct 9. J Pharmacol Exp Ther. 2014. PMID: 25301170 Clinical Trial.

2

Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species.

Geary RS, Yu RZ, Watanabe T, Henry SP, Hardee GE, Chappell A, Matson J, Sasmor H, Cummins L, Levin AA. Geary RS, et al. Among authors: chappell a. Drug Metab Dispos. 2003 Nov;31(11):1419-28. doi: 10.1124/dmd.31.11.1419. Drug Metab Dispos. 2003. PMID: 14570775

3

Targeted Delivery of Antisense Oligonucleotides Through Angiotensin Type 1 Receptor.

Kuo C, Nikan M, Yeh ST, Chappell AE, Tanowitz M, Seth PP, Prakash TP, Mullick AE. Kuo C, et al. Nucleic Acid Ther. 2022 Aug;32(4):300-311. doi: 10.1089/nat.2021.0105. Epub 2022 May 24. Nucleic Acid Ther. 2022. PMID: 35612431

4

Lipid nanoparticles improve activity of single-stranded siRNA and gapmer antisense oligonucleotides in animals.

Prakash TP, Lima WF, Murray HM, Elbashir S, Cantley W, Foster D, Jayaraman M, Chappell AE, Manoharan M, Swayze EE, Crooke ST. Prakash TP, et al. ACS Chem Biol. 2013 Jul 19;8(7):1402-6. doi: 10.1021/cb4001316. Epub 2013 May 2. ACS Chem Biol. 2013. PMID: 23614580

5

Solid-phase synthesis of 5'-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry.

Prakash TP, Brad Wan W, Low A, Yu J, Chappell AE, Gaus H, Kinberger GA, Østergaard ME, Migawa MT, Swayze EE, Seth PP. Prakash TP, et al. Among authors: chappell ae. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4127-30. doi: 10.1016/j.bmcl.2015.08.019. Epub 2015 Aug 8. Bioorg Med Chem Lett. 2015. PMID: 26299345

6

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice.

Prakash TP, Graham MJ, Yu J, Carty R, Low A, Chappell A, Schmidt K, Zhao C, Aghajan M, Murray HF, Riney S, Booten SL, Murray SF, Gaus H, Crosby J, Lima WF, Guo S, Monia BP, Swayze EE, Seth PP. Prakash TP, et al. Among authors: chappell a. Nucleic Acids Res. 2014 Jul;42(13):8796-807. doi: 10.1093/nar/gku531. Epub 2014 Jul 3. Nucleic Acids Res. 2014. PMID: 24992960 Free PMC article.

7

Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.

Kinberger GA, Prakash TP, Yu J, Vasquez G, Low A, Chappell A, Schmidt K, Murray HM, Gaus H, Swayze EE, Seth PP. Kinberger GA, et al. Among authors: chappell a. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3690-3. doi: 10.1016/j.bmcl.2016.05.084. Epub 2016 May 28. Bioorg Med Chem Lett. 2016. PMID: 27268307

8

Spinal distribution and metabolism of 2'-O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats.

Butler M, Hayes CS, Chappell A, Murray SF, Yaksh TL, Hua XY. Butler M, et al. Among authors: chappell a. Neuroscience. 2005;131(3):705-15. doi: 10.1016/j.neuroscience.2004.11.038. Neuroscience. 2005. PMID: 15730875

9

Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.

Prakash TP, Yu J, Migawa MT, Kinberger GA, Wan WB, Østergaard ME, Carty RL, Vasquez G, Low A, Chappell A, Schmidt K, Aghajan M, Crosby J, Murray HM, Booten SL, Hsiao J, Soriano A, Machemer T, Cauntay P, Burel SA, Murray SF, Gaus H, Graham MJ, Swayze EE, Seth PP. Prakash TP, et al. Among authors: chappell a. J Med Chem. 2016 Mar 24;59(6):2718-33. doi: 10.1021/acs.jmedchem.5b01948. Epub 2016 Mar 9. J Med Chem. 2016. PMID: 26914862

10

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes.

Koller E, Vincent TM, Chappell A, De S, Manoharan M, Bennett CF. Koller E, et al. Among authors: chappell a. Nucleic Acids Res. 2011 Jun;39(11):4795-807. doi: 10.1093/nar/gkr089. Epub 2011 Feb 23. Nucleic Acids Res. 2011. PMID: 21345934 Free PMC article.

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