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IgG Immune Complexes Inhibit Naïve T Cell Proliferation and Suppress Effector Function in Cytotoxic T Cells.
Front Immunol. 2021 Aug 10;12:713704. doi: 10.3389/fimmu.2021.713704. eCollection 2021.
Front Immunol. 2021.
PMID: 34447380
Free PMC article.
An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIaV158 Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated Macrophages.
Kang TH, Lee CH, Delidakis G, Jung J, Richard-Le Goff O, Lee J, Kim JE, Charab W, Bruhns P, Georgiou G.
Kang TH, et al. Among authors: charab w.
Front Immunol. 2019 Mar 27;10:562. doi: 10.3389/fimmu.2019.00562. eCollection 2019.
Front Immunol. 2019.
PMID: 30984171
Free PMC article.
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IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.
Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G.
Lee CH, et al. Among authors: charab w.
Nat Immunol. 2017 Aug;18(8):889-898. doi: 10.1038/ni.3770. Epub 2017 Jun 12.
Nat Immunol. 2017.
PMID: 28604720
Free PMC article.
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IgGA: a "cross-isotype" engineered human Fc antibody domain that displays both IgG-like and IgA-like effector functions.
Kelton W, Mehta N, Charab W, Lee J, Lee CH, Kojima T, Kang TH, Georgiou G.
Kelton W, et al. Among authors: charab w.
Chem Biol. 2014 Dec 18;21(12):1603-9. doi: 10.1016/j.chembiol.2014.10.017. Epub 2014 Dec 11.
Chem Biol. 2014.
PMID: 25500223
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In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire.
DeKosky BJ, Kojima T, Rodin A, Charab W, Ippolito GC, Ellington AD, Georgiou G.
DeKosky BJ, et al. Among authors: charab w.
Nat Med. 2015 Jan;21(1):86-91. doi: 10.1038/nm.3743. Epub 2014 Dec 15.
Nat Med. 2015.
PMID: 25501908
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Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires.
DeKosky BJ, Lungu OI, Park D, Johnson EL, Charab W, Chrysostomou C, Kuroda D, Ellington AD, Ippolito GC, Gray JJ, Georgiou G.
DeKosky BJ, et al. Among authors: charab w.
Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2636-45. doi: 10.1073/pnas.1525510113. Epub 2016 Apr 25.
Proc Natl Acad Sci U S A. 2016.
PMID: 27114511
Free PMC article.
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Corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.
Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G.
Lee CH, et al. Among authors: charab w.
Nat Immunol. 2017 Sep 19;18(10):1173. doi: 10.1038/ni1017-1173c.
Nat Immunol. 2017.
PMID: 28926542
No abstract available.
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Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells.
Romain G, Senyukov V, Rey-Villamizar N, Merouane A, Kelton W, Liadi I, Mahendra A, Charab W, Georgiou G, Roysam B, Lee DA, Varadarajan N.
Romain G, et al. Among authors: charab w.
Blood. 2014 Nov 20;124(22):3241-9. doi: 10.1182/blood-2014-04-569061. Epub 2014 Sep 16.
Blood. 2014.
PMID: 25232058
Free PMC article.
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