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Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.
Nguyen TP, Wang W, Sternisha AC, Corley CD, Wang HL, Wang X, Ortiz F, Lim SK, Abdullah KG, Parada LF, Williams NS, McBrayer SK, McDonald JG, De Brabander JK, Nijhawan D. Nguyen TP, et al. Among authors: corley cd. Cell Chem Biol. 2023 Feb 16;30(2):214-229.e18. doi: 10.1016/j.chembiol.2023.01.005. Epub 2023 Feb 8. Cell Chem Biol. 2023. PMID: 36758549 Free PMC article.
Intracellular lipid surveillance by small G protein geranylgeranylation.
Watterson A, Tatge L, Wajahat N, Arneaud SLB, Solano Fonseca R, Beheshti ST, Metang P, Mihelakis M, Zuurbier KR, Corley CD, Dehghan I, McDonald JG, Douglas PM. Watterson A, et al. Among authors: corley cd. Nature. 2022 May;605(7911):736-740. doi: 10.1038/s41586-022-04729-7. Epub 2022 May 18. Nature. 2022. PMID: 35585236 Free PMC article.
Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating Jmjd3.
Salloum Z, Dauner K, Li YF, Verma N, Valdivieso-González D, Almendro-Vedia VG, Zhang JD, Nakka K, Chen MX, McDonald JG, Corley CD, Sorisky A, Song BL, López-Montero I, Luo J, Dilworth JF, Zha X. Salloum Z, et al. Among authors: corley cd. Elife. 2024 Apr 11;13:e85964. doi: 10.7554/eLife.85964. Online ahead of print. Elife. 2024. PMID: 38602170 Free article.