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Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors.
Khanwelkar RR, Chen GS, Wang HC, Yu CW, Huang CH, Lee O, Chen CH, Hwang CS, Ko CH, Chou NT, Lin MW, Wang LM, Chen YC, Hseu TH, Chang CN, Hsu HC, Lin HC, Shih YC, Chou SH, Tseng HW, Liu CP, Tu CM, Hu TL, Tsai YJ, Chern JW. Khanwelkar RR, et al. Among authors: chen ch, chen gs, chen yc. Bioorg Med Chem. 2010 Jul 1;18(13):4674-86. doi: 10.1016/j.bmc.2010.05.021. Epub 2010 May 12. Bioorg Med Chem. 2010. PMID: 20570526
Novel azulene-based derivatives as potent multi-receptor tyrosine kinase inhibitors.
Chen CH, Lee O, Yao CN, Chuang MY, Chang YL, Chang MH, Wen YF, Yang WH, Ko CH, Chou NT, Lin MW, Lai CP, Sun CY, Wang LM, Chen YC, Hseu TH, Chang CN, Hsu HC, Lin HC, Chang YL, Shih YC, Chou SH, Hsu YL, Tseng HW, Liu CP, Tu CM, Hu TL, Tsai YJ, Chen TS, Lin CL, Chiou SJ, Liu CC, Hwang CS. Chen CH, et al. Among authors: chen ts, chen yc. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6129-32. doi: 10.1016/j.bmcl.2010.08.025. Epub 2010 Aug 10. Bioorg Med Chem Lett. 2010. PMID: 20833039
Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions.
Wen YT, Huang CW, Liu CP, Chen CH, Tu CM, Hwang CS, Chen YH, Chen WR, Lin KL, Ho YC, Chen TC, Tsai RK. Wen YT, et al. Among authors: chen yh, chen tc, chen ch, chen wr. Invest Ophthalmol Vis Sci. 2021 May 3;62(6):21. doi: 10.1167/iovs.62.6.21. Invest Ophthalmol Vis Sci. 2021. PMID: 34015079 Free PMC article.
The Intraocular Pressure Lowering Effect of a Dual Kinase Inhibitor (ITRI-E-(S)4046) in Ocular Hypertensive Animal Models.
Chen YH, Lin WY, Huang YC, Ho WY, Fu CW, Tu CM, Hwang CS, Hung CL, Lin MC, Cheng F, Wang YJ, Chen CH, Chou SH, She MP, Yang CY, Cheng HL, Liu CP, Lu DW. Chen YH, et al. Among authors: chen ch. Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):12. doi: 10.1167/iovs.62.13.12. Invest Ophthalmol Vis Sci. 2021. PMID: 34661609 Free PMC article.
A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia.
Hsu CR, Chen YH, Liu CP, Chen CH, Huang KK, Huang JW, Lin MN, Lin CL, Chen WR, Hsu YL, Lee TC, Chou SH, Tu CM, Hwang CS, Huang YC, Lu DW. Hsu CR, et al. Among authors: chen yh, chen ch, chen wr. Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):624-633. doi: 10.1167/iovs.18-25252. Invest Ophthalmol Vis Sci. 2019. PMID: 30735565
8,787 results