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DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.
Willemsen L, Prange KHM, Neele AE, van Roomen CPAA, Gijbels M, Griffith GR, Toom MD, Beckers L, Siebeler R, Spann NJ, Chen HJ, Bosmans LA, Gorbatenko A, van Wouw S, Zelcer N, Jacobs H, van Leeuwen F, de Winther MPJ. Willemsen L, et al. Among authors: chen hj. Cell Rep. 2022 Nov 22;41(8):111703. doi: 10.1016/j.celrep.2022.111703. Cell Rep. 2022. PMID: 36417856 Free article.
Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.
Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MC, Ahmed M, Hoeksema MA, de Vos AF, de Winther MP. Van den Bossche J, et al. Among authors: chen hj. Cell Rep. 2016 Oct 11;17(3):684-696. doi: 10.1016/j.celrep.2016.09.008. Cell Rep. 2016. PMID: 27732846 Free article.
Myeloid Kdm6b deficiency results in advanced atherosclerosis.
Neele AE, Gijbels MJJ, van der Velden S, Hoeksema MA, Boshuizen MCS, Prange KHM, Chen HJ, Van den Bossche J, van Roomen CPPA, Shami A, Levels JHM, Kroon J, Lucas T, Dimmeler S, Lutgens E, de Winther MPJ. Neele AE, et al. Among authors: chen hj. Atherosclerosis. 2018 Aug;275:156-165. doi: 10.1016/j.atherosclerosis.2018.05.052. Epub 2018 Jun 1. Atherosclerosis. 2018. PMID: 29908485 Free article.
Type-I interferons in atherosclerosis.
Chen HJ, Tas SW, de Winther MPJ. Chen HJ, et al. J Exp Med. 2020 Jan 6;217(1):e20190459. doi: 10.1084/jem.20190459. J Exp Med. 2020. PMID: 31821440 Free PMC article. Review.
Targeting epigenetics as atherosclerosis treatment: an updated view.
Neele AE, Willemsen L, Chen HJ, Dzobo KE, de Winther MPJ. Neele AE, et al. Among authors: chen hj. Curr Opin Lipidol. 2020 Dec;31(6):324-330. doi: 10.1097/MOL.0000000000000711. Curr Opin Lipidol. 2020. PMID: 33027226 Free PMC article. Review.
Myeloid Ezh2 Deficiency Limits Atherosclerosis Development.
Neele AE, Chen HJ, Gijbels MJJ, van der Velden S, Hoeksema MA, Boshuizen MCS, Van den Bossche J, Tool AT, Matlung HL, van den Berg TK, Lutgens E, de Winther MPJ. Neele AE, et al. Among authors: chen hj. Front Immunol. 2021 Jan 26;11:594603. doi: 10.3389/fimmu.2020.594603. eCollection 2020. Front Immunol. 2021. PMID: 33574814 Free PMC article.
High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages.
Hoepel W, Chen HJ, Geyer CE, Allahverdiyeva S, Manz XD, de Taeye SW, Aman J, Mes L, Steenhuis M, Griffith GR, Bonta PI, Brouwer PJM, Caniels TG, van der Straten K, Golebski K, Jonkers RE, Larsen MD, Linty F, Nouta J, van Roomen CPAA, van Baarle FEHP, van Drunen CM, Wolbink G, Vlaar APJ, de Bree GJ, Sanders RW, Willemsen L, Neele AE, van de Beek D, Rispens T, Wuhrer M, Bogaard HJ, van Gils MJ, Vidarsson G, de Winther M, den Dunnen J. Hoepel W, et al. Among authors: chen hj. Sci Transl Med. 2021 Jun 2;13(596):eabf8654. doi: 10.1126/scitranslmed.abf8654. Epub 2021 May 11. Sci Transl Med. 2021. PMID: 33979301 Free PMC article.
C-Reactive Protein Controls IL-23 Production by Human Monocytes.
Geyer CE, Newling M, Sritharan L, Griffith GR, Chen HJ, Baeten DLP, den Dunnen J. Geyer CE, et al. Among authors: chen hj. Int J Mol Sci. 2021 Oct 28;22(21):11638. doi: 10.3390/ijms222111638. Int J Mol Sci. 2021. PMID: 34769069 Free PMC article.
1,894 results