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Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.
Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS. Princen F, et al. Among authors: chen j, chen y. Mol Cell Biol. 2009 Jan;29(2):378-88. doi: 10.1128/MCB.01661-08. Epub 2008 Nov 10. Mol Cell Biol. 2009. PMID: 19001090 Free PMC article.
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice.
Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW 2nd, Brown JH, Peterson KL, Omens JH, McCulloch AD, Chen J. Sheikh F, et al. Among authors: chen j. J Clin Invest. 2008 Dec;118(12):3870-80. doi: 10.1172/JCI34472. Epub 2008 Nov 3. J Clin Invest. 2008. PMID: 19033658 Free PMC article.
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