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Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models.
Hakim CH, Kumar SRP, Pérez-López DO, Wasala NB, Zhang D, Yue Y, Teixeira J, Pan X, Zhang K, Million ED, Nelson CE, Metzger S, Han J, Louderman JA, Schmidt F, Feng F, Grimm D, Smith BF, Yao G, Yang NN, Gersbach CA, Chen SJ, Herzog RW, Duan D. Hakim CH, et al. Among authors: chen sj. Nat Commun. 2021 Nov 24;12(1):6769. doi: 10.1038/s41467-021-26830-7. Nat Commun. 2021. PMID: 34819506 Free PMC article.
Nanopore electric snapshots of an RNA tertiary folding pathway.
Zhang X, Zhang D, Zhao C, Tian K, Shi R, Du X, Burcke AJ, Wang J, Chen SJ, Gu LQ. Zhang X, et al. Among authors: chen sj. Nat Commun. 2017 Nov 13;8(1):1458. doi: 10.1038/s41467-017-01588-z. Nat Commun. 2017. PMID: 29133841 Free PMC article.
AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice.
Hakim CH, Wasala NB, Nelson CE, Wasala LP, Yue Y, Louderman JA, Lessa TB, Dai A, Zhang K, Jenkins GJ, Nance ME, Pan X, Kodippili K, Yang NN, Chen SJ, Gersbach CA, Duan D. Hakim CH, et al. Among authors: chen sj. JCI Insight. 2018 Dec 6;3(23):e124297. doi: 10.1172/jci.insight.124297. JCI Insight. 2018. PMID: 30518686 Free PMC article.
AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice.
Nance ME, Shi R, Hakim CH, Wasala NB, Yue Y, Pan X, Zhang T, Robinson CA, Duan SX, Yao G, Yang NN, Chen SJ, Wagner KR, Gersbach CA, Duan D. Nance ME, et al. Among authors: chen sj. Mol Ther. 2019 Sep 4;27(9):1568-1585. doi: 10.1016/j.ymthe.2019.06.012. Epub 2019 Jul 3. Mol Ther. 2019. PMID: 31327755 Free PMC article.
3,023 results