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UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.
Moore C, Cevikbas F, Pasolli HA, Chen Y, Kong W, Kempkes C, Parekh P, Lee SH, Kontchou NA, Yeh I, Jokerst NM, Fuchs E, Steinhoff M, Liedtke WB. Moore C, et al. Among authors: chen y. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3225-34. doi: 10.1073/pnas.1312933110. Epub 2013 Aug 8. Proc Natl Acad Sci U S A. 2013. PMID: 23929777 Free PMC article.
TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.
Chen Y, Moore CD, Zhang JY, Hall RP 3rd, MacLeod AS, Liedtke W. Chen Y, et al. J Invest Dermatol. 2017 Apr;137(4):801-804. doi: 10.1016/j.jid.2016.12.013. J Invest Dermatol. 2017. PMID: 28340683 Free PMC article.
A craniofacial-specific monosynaptic circuit enables heightened affective pain.
Rodriguez E, Sakurai K, Xu J, Chen Y, Toda K, Zhao S, Han BX, Ryu D, Yin H, Liedtke W, Wang F. Rodriguez E, et al. Among authors: chen y. Nat Neurosci. 2017 Dec;20(12):1734-1743. doi: 10.1038/s41593-017-0012-1. Epub 2017 Nov 13. Nat Neurosci. 2017. PMID: 29184209 Free PMC article.
Regulation of Pain and Itch by TRP Channels.
Moore C, Gupta R, Jordt SE, Chen Y, Liedtke WB. Moore C, et al. Among authors: chen y. Neurosci Bull. 2018 Feb;34(1):120-142. doi: 10.1007/s12264-017-0200-8. Epub 2017 Dec 27. Neurosci Bull. 2018. PMID: 29282613 Free PMC article. Review.
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