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Directed Evolution of an Enhanced POU Reprogramming Factor for Cell Fate Engineering.
Tan DS, Chen Y, Gao Y, Bednarz A, Wei Y, Malik V, Ho DH, Weng M, Ho SY, Srivastava Y, Velychko S, Yang X, Fan L, Kim J, Graumann J, Stormo GD, Braun T, Yan J, Schöler HR, Jauch R. Tan DS, et al. Among authors: chen y. Mol Biol Evol. 2021 Jun 25;38(7):2854-2868. doi: 10.1093/molbev/msab075. Mol Biol Evol. 2021. PMID: 33720298 Free PMC article.
Changing POU dimerization preferences converts Oct6 into a pluripotency inducer.
Jerabek S, Ng CK, Wu G, Arauzo-Bravo MJ, Kim KP, Esch D, Malik V, Chen Y, Velychko S, MacCarthy CM, Yang X, Cojocaru V, Schöler HR, Jauch R. Jerabek S, et al. Among authors: chen y. EMBO Rep. 2017 Feb;18(2):319-333. doi: 10.15252/embr.201642958. Epub 2016 Dec 22. EMBO Rep. 2017. PMID: 28007765 Free PMC article.
Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2.
Malik V, Glaser LV, Zimmer D, Velychko S, Weng M, Holzner M, Arend M, Chen Y, Srivastava Y, Veerapandian V, Shah Z, Esteban MA, Wang H, Chen J, Schöler HR, Hutchins AP, Meijsing SH, Pott S, Jauch R. Malik V, et al. Among authors: chen j, chen y. Nat Commun. 2019 Aug 2;10(1):3477. doi: 10.1038/s41467-019-11054-7. Nat Commun. 2019. PMID: 31375664 Free PMC article.
The homeobox transcription factor DUXBL controls exit from totipotency.
Vega-Sendino M, Lüttmann FF, Olbrich T, Chen Y, Kuenne C, Stein P, Tillo D, Carey GI, Zhong J, Savy V, Radonova L, Lu T, Saykali B, Kim KP, Domingo CN, Schüler L, Günther S, Bentsen M, Bosnakovski D, Schöler H, Kyba M, Maity TK, Jenkins LM, Looso M, Williams CJ, Kim J, Ruiz S. Vega-Sendino M, et al. Among authors: chen y. Nat Genet. 2024 Apr;56(4):697-709. doi: 10.1038/s41588-024-01692-z. Epub 2024 Mar 20. Nat Genet. 2024. PMID: 38509386
Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation.
Zhu Y, Ackers-Johnson M, Shanmugam MK, Pakkiri LS, Drum CL, Chen Y, Kim J, Paltzer WG, Mahmoud AI, Wen Tan WL, Lee MCJ, Jiang J, Luu DAT, Ng SL, Li PYQ, Wang A, Qi R, Ong GJX, Ng Yu T, Haigh JJ, Tiang Z, Richards AM, Foo R. Zhu Y, et al. Among authors: chen y. Circulation. 2024 Apr 8. doi: 10.1161/CIRCULATIONAHA.123.063965. Online ahead of print. Circulation. 2024. PMID: 38586957
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