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PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.
Xiao Y, Yeong Chit Chia J, Gajewski JE, Sio Seng Lio D, Mulhern TD, Zhu HJ, Nandurkar H, Cheng HC. Xiao Y, et al. Among authors: cheng hc. Cell Signal. 2007 Jul;19(7):1434-45. doi: 10.1016/j.cellsig.2007.01.021. Epub 2007 Jan 25. Cell Signal. 2007. PMID: 17324556
Src family kinases and their role in hematological malignancies.
Ku M, Wall M, MacKinnon RN, Walkley CR, Purton LE, Tam C, Izon D, Campbell L, Cheng HC, Nandurkar H. Ku M, et al. Among authors: cheng hc. Leuk Lymphoma. 2015 Mar;56(3):577-86. doi: 10.3109/10428194.2014.907897. Epub 2015 Jan 21. Leuk Lymphoma. 2015. PMID: 24898666 Review.
CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation.
Chüeh AC, Advani G, Foroutan M, Smith J, Ng N, Nandurkar H, Lio DS, Zhu HJ, Chong YP, Verkade H, Fujita DJ, Bjorge J, Basheer F, Lim JP, Luk I, Dhillon A, Sakthianandeswaren A, Mouradov D, Sieber O, Hollande F, Mariadason JM, Cheng HC. Chüeh AC, et al. Among authors: cheng hc. Oncogene. 2021 Apr;40(17):3015-3029. doi: 10.1038/s41388-021-01755-z. Epub 2021 Mar 25. Oncogene. 2021. PMID: 33767439
N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection.
Ameen SS, Griem-Krey N, Dufour A, Hossain MI, Hoque A, Sturgeon S, Nandurkar H, Draxler DF, Medcalf RL, Kamaruddin MA, Lucet IS, Leeming MG, Liu D, Dhillon A, Lim JP, Basheer F, Zhu HJ, Bokhari L, Roulston CL, Paradkar PN, Kleifeld O, Clarkson AN, Wellendorph P, Ciccotosto GD, Williamson NA, Ang CS, Cheng HC. Ameen SS, et al. Among authors: cheng hc. Mol Cell Proteomics. 2023 May;22(5):100543. doi: 10.1016/j.mcpro.2023.100543. Epub 2023 Apr 6. Mol Cell Proteomics. 2023. PMID: 37030595 Free PMC article.
Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.
Advani G, Lim YC, Catimel B, Lio DSS, Ng NLY, Chüeh AC, Tran M, Anasir MI, Verkade H, Zhu HJ, Turk BE, Smithgall TE, Ang CS, Griffin M, Cheng HC. Advani G, et al. Among authors: cheng hc. Cell Commun Signal. 2017 Aug 7;15(1):29. doi: 10.1186/s12964-017-0186-x. Cell Commun Signal. 2017. PMID: 28784162 Free PMC article.
969 results