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A preferential p110alpha/gamma PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-kappaB-dependent manner.
Dagia NM, Agarwal G, Kamath DV, Chetrapal-Kunwar A, Gupte RD, Jadhav MG, Dadarkar SS, Trivedi J, Kulkarni-Almeida AA, Kharas F, Fonseca LC, Kumar S, Bhonde MR. Dagia NM, et al. Among authors: chetrapal kunwar a. Am J Physiol Cell Physiol. 2010 Apr;298(4):C929-41. doi: 10.1152/ajpcell.00461.2009. Epub 2010 Jan 20. Am J Physiol Cell Physiol. 2010. PMID: 20089935 Free article.
A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis.
Dagia NM, Kamath DV, Bhatt P, Gupte RD, Dadarkar SS, Fonseca L, Agarwal G, Chetrapal-Kunwar A, Balachandran S, Srinivasan S, Bose J, Pari K, B-Rao C, Parkale SS, Gadekar PK, Rodge AH, Mandrekar N, Vishwakarma RA, Sharma S. Dagia NM, et al. Among authors: chetrapal kunwar a. Eur J Pharmacol. 2009 Apr 1;607(1-3):201-12. doi: 10.1016/j.ejphar.2009.02.031. Epub 2009 Feb 21. Eur J Pharmacol. 2009. PMID: 19239912
Novel derivatives of ISO-1 as potent inhibitors of MIF biological function.
Balachandran S, Rodge A, Gadekar PK, Yadav VN, Kamath D, Chetrapal-Kunwar A, Bhatt P, Srinivasan S, Sharma S, Vishwakarma RA, Dagia NM. Balachandran S, et al. Among authors: chetrapal kunwar a. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4773-6. doi: 10.1016/j.bmcl.2009.06.052. Epub 2009 Jun 17. Bioorg Med Chem Lett. 2009. PMID: 19592246