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Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.
Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson DW, Lewis J. Ahmed Z, et al. Among authors: chiba s. Am J Pathol. 2010 Jul;177(1):311-24. doi: 10.2353/ajpath.2010.090915. Epub 2010 Jun 3. Am J Pathol. 2010. PMID: 20522652 Free PMC article.
Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex.
Chiba S, Numakawa T, Ninomiya M, Richards MC, Wakabayashi C, Kunugi H. Chiba S, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):112-9. doi: 10.1016/j.pnpbp.2012.05.018. Epub 2012 Jun 1. Prog Neuropsychopharmacol Biol Psychiatry. 2012. PMID: 22664354
2,656 results