Chicchi G - Search Results

1

Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus.

Maubach KA, Martin K, Chicchi G, Harrison T, Wheeldon A, Swain CJ, Cumberbatch MJ, Rupniak NM, Seabrook GR. Maubach KA, et al. Among authors: chicchi g. Neuroscience. 2002;109(3):609-17. doi: 10.1016/s0306-4522(01)00467-5. Neuroscience. 2002. PMID: 11823070

2

Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608.

Rupniak NM, Carlson EJ, Shepheard S, Bentley G, Williams AR, Hill A, Swain C, Mills SG, Di Salvo J, Kilburn R, Cascieri MA, Kurtz MM, Tsao KL, Gould SL, Chicchi GG. Rupniak NM, et al. Among authors: chicchi gg. Neuropharmacology. 2003 Aug;45(2):231-41. doi: 10.1016/s0028-3908(03)00157-6. Neuropharmacology. 2003. PMID: 12842129

3

Distinct mechanism for antidepressant activity by blockade of central substance P receptors.

Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Carlson EJ, Hargreaves RJ, Rupniak NM. Kramer MS, et al. Among authors: chicchi gg. Science. 1998 Sep 11;281(5383):1640-5. doi: 10.1126/science.281.5383.1640. Science. 1998. PMID: 9733503 Clinical Trial.

4

4,4-Disubstituted piperidine high-affinity NK1 antagonists: structure-activity relationships and in vivo activity.

Stevenson GI, Huscroft I, MacLeod AM, Swain CJ, Cascieri MA, Chicchi GG, Graham MI, Harrison T, Kelleher FJ, Kurtz M, Ladduwahetty T, Merchant KJ, Metzger JM, MacIntyre DE, Sadowski S, Sohal B, Owens AP. Stevenson GI, et al. Among authors: chicchi gg. J Med Chem. 1998 Nov 5;41(23):4623-35. doi: 10.1021/jm980376b. J Med Chem. 1998. PMID: 9804702

5

An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration.

Harrison T, Owens AP, Williams BJ, Swain CJ, Williams A, Carlson EJ, Rycroft W, Tattersall FD, Cascieri MA, Chicchi GG, Sadowski S, Rupniak NM, Hargreaves RJ. Harrison T, et al. Among authors: chicchi gg. J Med Chem. 2001 Nov 22;44(24):4296-9. doi: 10.1021/jm0109558. J Med Chem. 2001. PMID: 11708932

6

Spirocyclic NK(1) antagonists II: [4.5]-spiroethers.

Williams BJ, Cascieri MA, Chicchi GG, Harrison T, Owens AP, Owen SN, Rupniak NM, Tattersall DF, Williams A, Swain CJ. Williams BJ, et al. Among authors: chicchi gg. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2719-22. doi: 10.1016/s0960-894x(02)00509-7. Bioorg Med Chem Lett. 2002. PMID: 12217362

7

Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists.

Thomson CG, Carlson E, Chicchi GG, Kulagowski JJ, Kurtz MM, Swain CJ, Tsao KL, Wheeldon A. Thomson CG, et al. Among authors: chicchi gg. Bioorg Med Chem Lett. 2006 Feb 15;16(4):811-4. doi: 10.1016/j.bmcl.2005.11.026. Epub 2005 Nov 22. Bioorg Med Chem Lett. 2006. PMID: 16307878

8

2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution.

Cooper LC, Chicchi GG, Dinnell K, Elliott JM, Hollingworth GJ, Kurtz MM, Locker KL, Morrison D, Shaw DE, Tsao KL, Watt AP, Williams AR, Swain CJ. Cooper LC, et al. Among authors: chicchi gg. Bioorg Med Chem Lett. 2001 May 7;11(9):1233-6. doi: 10.1016/s0960-894x(01)00182-2. Bioorg Med Chem Lett. 2001. PMID: 11354384

9

2-Aryl indole NK1 receptor antagonists: optimisation of the 2-aryl ring and the indole nitrogen substituent.

Dinnell K, Chicchi GG, Dhar MJ, Elliott JM, Hollingworth GJ, Kurtz MM, Ridgill MP, Rycroft W, Tsao KL, Williams AR, Swain CJ. Dinnell K, et al. Among authors: chicchi gg. Bioorg Med Chem Lett. 2001 May 7;11(9):1237-40. doi: 10.1016/s0960-894x(01)00183-4. Bioorg Med Chem Lett. 2001. PMID: 11354385

10

Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor.

Morriello GJ, Chicchi G, Johnson T, Mills SG, Demartino J, Kurtz M, Tsao KL, Zheng S, Tong X, Carlson E, Townson K, Wheeldon A, Boyce S, Collinson N, Rupniak N, Devita RJ. Morriello GJ, et al. Among authors: chicchi g. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5925-32. doi: 10.1016/j.bmcl.2010.07.058. Epub 2010 Jul 19. Bioorg Med Chem Lett. 2010. PMID: 20729082

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