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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors.
Cell Rep. 2023 May 30;42(5):112538. doi: 10.1016/j.celrep.2023.112538. Epub 2023 May 19.
Cell Rep. 2023.
PMID: 37209095
Free PMC article.
Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance.
Andronikou C, Rottenberg S.
Andronikou C, et al.
Trends Mol Med. 2021 Jul;27(7):630-642. doi: 10.1016/j.molmed.2021.04.010. Epub 2021 May 21.
Trends Mol Med. 2021.
PMID: 34030964
Free article.
Review.
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PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair.
Andronikou C, Burdova K, Dibitetto D, Lieftink C, Malzer E, Kuiken HJ, Gogola E, Ray Chaudhuri A, Beijersbergen RL, Hanzlikova H, Jonkers J, Rottenberg S.
Andronikou C, et al.
EMBO J. 2024 Mar;43(6):1015-1042. doi: 10.1038/s44318-024-00043-2. Epub 2024 Feb 15.
EMBO J. 2024.
PMID: 38360994
Free PMC article.
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