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Page 1
Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice.
Drewes JL, Chen J, Markham NO, Knippel RJ, Domingue JC, Tam AJ, Chan JL, Kim L, McMann M, Stevens C, Dejea CM, Tomkovich S, Michel J, White JR, Mohammad F, Campodónico VL, Heiser CN, Wu X, Wu S, Ding H, Simner P, Carroll K, Shrubsole MJ, Anders RA, Walk ST, Jobin C, Wan F, Coffey RJ, Housseau F, Lau KS, Sears CL. Drewes JL, et al. Among authors: dejea cm. Cancer Discov. 2022 Aug 5;12(8):1873-1885. doi: 10.1158/2159-8290.CD-21-1273. Cancer Discov. 2022. PMID: 35678528 Free PMC article.
Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy.
DeStefano Shields CE, White JR, Chung L, Wenzel A, Hicks JL, Tam AJ, Chan JL, Dejea CM, Fan H, Michel J, Maiuri AR, Sriramkumar S, Podicheti R, Rusch DB, Wang H, De Marzo AM, Besharati S, Anders RA, Baylin SB, O'Hagan HM, Housseau F, Sears CL. DeStefano Shields CE, et al. Among authors: dejea cm. Cancer Discov. 2021 Jul;11(7):1792-1807. doi: 10.1158/2159-8290.CD-20-0770. Epub 2021 Feb 25. Cancer Discov. 2021. PMID: 33632774 Free PMC article.
Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic.
Tomkovich S, Dejea CM, Winglee K, Drewes JL, Chung L, Housseau F, Pope JL, Gauthier J, Sun X, Mühlbauer M, Liu X, Fathi P, Anders RA, Besharati S, Perez-Chanona E, Yang Y, Ding H, Wu X, Wu S, White JR, Gharaibeh RZ, Fodor AA, Wang H, Pardoll DM, Jobin C, Sears CL. Tomkovich S, et al. Among authors: dejea cm. J Clin Invest. 2019 Mar 11;129(4):1699-1712. doi: 10.1172/JCI124196. eCollection 2019 Mar 11. J Clin Invest. 2019. PMID: 30855275 Free PMC article.
Erratum: Author Correction: High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia.
Drewes JL, White JR, Dejea CM, Fathi P, Iyadorai T, Vadivelu J, Roslani AC, Wick EC, Mongodin EF, Loke MF, Thulasi K, Gan HM, Goh KL, Chong HY, Kumar S, Wanyiri JW, Sears CL. Drewes JL, et al. Among authors: dejea cm. NPJ Biofilms Microbiomes. 2019 Jan 9;5(1):2. doi: 10.1038/s41522-018-0078-x. eCollection 2019. NPJ Biofilms Microbiomes. 2019. PMID: 30652010 Free PMC article.
Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
Chung L, Orberg ET, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F. Chung L, et al. Among authors: dejea cm. Cell Host Microbe. 2018 Mar 14;23(3):421. doi: 10.1016/j.chom.2018.02.004. Cell Host Microbe. 2018. PMID: 29544099 Free PMC article. No abstract available.
Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F. Chung L, et al. Among authors: dejea cm. Cell Host Microbe. 2018 Feb 14;23(2):203-214.e5. doi: 10.1016/j.chom.2018.01.007. Epub 2018 Feb 1. Cell Host Microbe. 2018. PMID: 29398651 Free PMC article.
High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia.
Drewes JL, White JR, Dejea CM, Fathi P, Iyadorai T, Vadivelu J, Roslani AC, Wick EC, Mongodin EF, Loke MF, Thulasi K, Gan HM, Goh KL, Chong HY, Kumar S, Wanyiri JW, Sears CL. Drewes JL, et al. Among authors: dejea cm. NPJ Biofilms Microbiomes. 2017 Nov 29;3:34. doi: 10.1038/s41522-017-0040-3. eCollection 2017. NPJ Biofilms Microbiomes. 2017. PMID: 29214046 Free PMC article.
Do biofilms confer a pro-carcinogenic state?
Dejea CM, Sears CL. Dejea CM, et al. Gut Microbes. 2016;7(1):54-7. doi: 10.1080/19490976.2015.1121363. Gut Microbes. 2016. PMID: 26939852 Free PMC article.
12 results