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Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.
Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC. Gonzalez Herrera KN, et al. Among authors: clish cb. Cell Rep. 2018 Feb 20;22(8):1945-1955. doi: 10.1016/j.celrep.2018.01.076. Cell Rep. 2018. PMID: 29466723 Free PMC article.
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. Zhong L, et al. Among authors: clish cb. Cell. 2010 Jan 22;140(2):280-93. doi: 10.1016/j.cell.2009.12.041. Cell. 2010. PMID: 20141841 Free PMC article.
Metabolite profiling identifies markers of uremia.
Rhee EP, Souza A, Farrell L, Pollak MR, Lewis GD, Steele DJ, Thadhani R, Clish CB, Greka A, Gerszten RE. Rhee EP, et al. Among authors: clish cb. J Am Soc Nephrol. 2010 Jun;21(6):1041-1051. doi: 10.1681/ASN.2009111132. Epub 2010 Apr 8. J Am Soc Nephrol. 2010. PMID: 20378825 Free PMC article.
Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, Manning BD. Düvel K, et al. Among authors: clish cb. Mol Cell. 2010 Jul 30;39(2):171-83. doi: 10.1016/j.molcel.2010.06.022. Mol Cell. 2010. PMID: 20670887 Free PMC article.
Targeted metabolomics.
Roberts LD, Souza AL, Gerszten RE, Clish CB. Roberts LD, et al. Among authors: clish cb. Curr Protoc Mol Biol. 2012 Apr;Chapter 30:Unit 30.2.1-24. doi: 10.1002/0471142727.mb3002s98. Curr Protoc Mol Biol. 2012. PMID: 22470063 Free PMC article.
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.
Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA, Armstrong SA. Kalaitzidis D, et al. Among authors: clish cb. Cell Stem Cell. 2012 Sep 7;11(3):429-39. doi: 10.1016/j.stem.2012.06.009. Cell Stem Cell. 2012. PMID: 22958934 Free PMC article.
480 results