Cochran JR - Search Results

1

Engineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand.

Kim JW, Marquez CP, Sperberg RAP, Wu J, Bae WG, Huang PS, Sweet-Cordero EA, Cochran JR. Kim JW, et al. Among authors: cochran jr. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14110-14118. doi: 10.1073/pnas.1922729117. Epub 2020 Jun 10. Proc Natl Acad Sci U S A. 2020. PMID: 32522868 Free PMC article.

2

Developing therapeutic proteins by engineering ligand-receptor interactions.

Jones DS, Silverman AP, Cochran JR. Jones DS, et al. Among authors: cochran jr. Trends Biotechnol. 2008 Sep;26(9):498-505. doi: 10.1016/j.tibtech.2008.05.009. Epub 2008 Jul 31. Trends Biotechnol. 2008. PMID: 18675482 Review.

3

Engineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists.

Jones DS 2nd, Tsai PC, Cochran JR. Jones DS 2nd, et al. Among authors: cochran jr. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13035-40. doi: 10.1073/pnas.1102561108. Epub 2011 Jul 25. Proc Natl Acad Sci U S A. 2011. PMID: 21788476 Free PMC article.

4

Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and alphavbeta3 integrin.

Papo N, Silverman AP, Lahti JL, Cochran JR. Papo N, et al. Among authors: cochran jr. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14067-72. doi: 10.1073/pnas.1016635108. Epub 2011 Aug 8. Proc Natl Acad Sci U S A. 2011. PMID: 21825147 Free PMC article.

5

Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma.

Moore SJ, Hayden Gephart MG, Bergen JM, Su YS, Rayburn H, Scott MP, Cochran JR. Moore SJ, et al. Among authors: cochran jr. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14598-603. doi: 10.1073/pnas.1311333110. Epub 2013 Aug 15. Proc Natl Acad Sci U S A. 2013. PMID: 23950221 Free PMC article.

6

A chemically cross-linked knottin dimer binds integrins with picomolar affinity and inhibits tumor cell migration and proliferation.

Kim JW, Cochran FV, Cochran JR. Kim JW, et al. Among authors: cochran fv, cochran jr. J Am Chem Soc. 2015 Jan 14;137(1):6-9. doi: 10.1021/ja508416e. Epub 2014 Dec 22. J Am Chem Soc. 2015. PMID: 25486381 Free PMC article.

7

Targeting ligand-receptor interactions for development of cancer therapeutics.

Kim JW, Cochran JR. Kim JW, et al. Among authors: cochran jr. Curr Opin Chem Biol. 2017 Jun;38:62-69. doi: 10.1016/j.cbpa.2017.03.010. Epub 2017 Mar 31. Curr Opin Chem Biol. 2017. PMID: 28371692 Review.

8

Structure and Functional Binding Epitope of V-domain Ig Suppressor of T Cell Activation.

Mehta N, Maddineni S, Mathews II, Andres Parra Sperberg R, Huang PS, Cochran JR. Mehta N, et al. Among authors: cochran jr. Cell Rep. 2019 Sep 3;28(10):2509-2516.e5. doi: 10.1016/j.celrep.2019.07.073. Cell Rep. 2019. PMID: 31484064 Free article.

9

Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma.

Kim JW, Marquez CP, Kostyrko K, Koehne AL, Marini K, Simpson DR, Lee AG, Leung SG, Sayles LC, Shrager J, Ferrer I, Paz-Ares L, Gephart MH, Vicent S, Cochran JR, Sweet-Cordero EA. Kim JW, et al. Among authors: cochran jr. Nat Med. 2019 Nov;25(11):1783-1795. doi: 10.1038/s41591-019-0612-2. Epub 2019 Nov 7. Nat Med. 2019. PMID: 31700175 Free PMC article.

10

Identification of N-Terminally Diversified GLP-1R Agonists Using Saturation Mutagenesis and Chemical Design.

Longwell CK, Hanna S, Hartrampf N, Sperberg RAP, Huang PS, Pentelute BL, Cochran JR. Longwell CK, et al. Among authors: cochran jr. ACS Chem Biol. 2021 Jan 15;16(1):58-66. doi: 10.1021/acschembio.0c00722. Epub 2020 Dec 14. ACS Chem Biol. 2021. PMID: 33307682 Free PMC article.

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