Cohen MS - Search Results

1

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.

Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. Shahbazian D, et al. Among authors: cohen ms. EMBO J. 2006 Jun 21;25(12):2781-91. doi: 10.1038/sj.emboj.7601166. Epub 2006 Jun 8. EMBO J. 2006. PMID: 16763566 Free PMC article.

2

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.

Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. Roux PP, et al. Among authors: cohen ms. J Biol Chem. 2007 May 11;282(19):14056-64. doi: 10.1074/jbc.M700906200. Epub 2007 Mar 14. J Biol Chem. 2007. PMID: 17360704 Free PMC article.

3

Structural bioinformatics-based design of selective, irreversible kinase inhibitors.

Cohen MS, Zhang C, Shokat KM, Taunton J. Cohen MS, et al. Science. 2005 May 27;308(5726):1318-21. doi: 10.1126/science1108367. Science. 2005. PMID: 15919995 Free PMC article.

4

Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation.

Cuello F, Snabaitis AK, Cohen MS, Taunton J, Avkiran M. Cuello F, et al. Among authors: cohen ms. Mol Pharmacol. 2007 Mar;71(3):799-806. doi: 10.1124/mol.106.029900. Epub 2006 Dec 1. Mol Pharmacol. 2007. PMID: 17142297

5

A clickable inhibitor reveals context-dependent autoactivation of p90 RSK.

Cohen MS, Hadjivassiliou H, Taunton J. Cohen MS, et al. Nat Chem Biol. 2007 Mar;3(3):156-60. doi: 10.1038/nchembio859. Epub 2007 Jan 28. Nat Chem Biol. 2007. PMID: 17259979 Free PMC article.

6

FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.

Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J. Kang S, et al. Among authors: cohen ms. Cancer Cell. 2007 Sep;12(3):201-14. doi: 10.1016/j.ccr.2007.08.003. Cancer Cell. 2007. PMID: 17785202 Free PMC article.

7

The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function.

Chaturvedi D, Cohen MS, Taunton J, Patel TB. Chaturvedi D, et al. Among authors: cohen ms. J Biol Chem. 2009 Aug 28;284(35):23670-81. doi: 10.1074/jbc.M109.032813. Epub 2009 Jul 1. J Biol Chem. 2009. PMID: 19570980 Free PMC article.

8

RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity.

Lee S, Shuman JD, Guszczynski T, Sakchaisri K, Sebastian T, Copeland TD, Miller M, Cohen MS, Taunton J, Smart RC, Xiao Z, Yu LR, Veenstra TD, Johnson PF. Lee S, et al. Among authors: cohen ms. Mol Cell Biol. 2010 Jun;30(11):2621-35. doi: 10.1128/MCB.00782-09. Epub 2010 Mar 29. Mol Cell Biol. 2010. PMID: 20351173 Free PMC article.

9

Rapamycin induces transactivation of the EGFR and increases cell survival.

Chaturvedi D, Gao X, Cohen MS, Taunton J, Patel TB. Chaturvedi D, et al. Among authors: cohen ms. Oncogene. 2009 Mar 5;28(9):1187-96. doi: 10.1038/onc.2008.490. Epub 2009 Jan 19. Oncogene. 2009. PMID: 19151764 Free PMC article.

10

RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.

Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen JV, Cohen MS, Johansen JV, Winther BR, Lund LR, Winther O, Taunton J, Hansen SH, Frödin M. Doehn U, et al. Among authors: cohen ms. Mol Cell. 2009 Aug 28;35(4):511-22. doi: 10.1016/j.molcel.2009.08.002. Mol Cell. 2009. PMID: 19716794 Free PMC article.

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