Cook J - Search Results

1

The α6 subunit-containing GABA_A receptor: A novel drug target for inhibition of trigeminal activation.

Fan PC, Lai TH, Hor CC, Lee MT, Huang P, Sieghart W, Ernst M, Knutson DE, Cook J, Chiou LC. Fan PC, et al. Among authors: cook j. Neuropharmacology. 2018 Sep 15;140:1-13. doi: 10.1016/j.neuropharm.2018.07.017. Epub 2018 Jul 21. Neuropharmacology. 2018. PMID: 30016665 Free PMC article.

2

Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors.

Zhang P, Zhang W, Liu R, Harris B, Skolnick P, Cook JM. Zhang P, et al. Among authors: cook jm. J Med Chem. 1995 May 12;38(10):1679-88. doi: 10.1021/jm00010a013. J Med Chem. 1995. PMID: 7752192

3

Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors.

Liu R, Hu RJ, Zhang P, Skolnick P, Cook JM. Liu R, et al. Among authors: cook jm. J Med Chem. 1996 Apr 26;39(9):1928-34. doi: 10.1021/jm950887n. J Med Chem. 1996. PMID: 8627617

4

Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist.

Li X, Cao H, Zhang C, Furtmueller R, Fuchs K, Huck S, Sieghart W, Deschamps J, Cook JM. Li X, et al. Among authors: cook jm. J Med Chem. 2003 Dec 18;46(26):5567-70. doi: 10.1021/jm034164c. J Med Chem. 2003. PMID: 14667209

5

Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?

Savić MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradović DI, Ugresić ND, Sieghart W, Bokonjić DR, Cook JM. Savić MM, et al. Neuropsychopharmacology. 2008 Jan;33(2):332-9. doi: 10.1038/sj.npp.1301403. Epub 2007 Mar 28. Neuropsychopharmacology. 2008. PMID: 17392731

6

An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models.

Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM. Clayton T, et al. Among authors: cook jm. Curr Med Chem. 2007;14(26):2755-75. doi: 10.2174/092986707782360097. Curr Med Chem. 2007. PMID: 18045122 Review.

7

PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats.

Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM. Savić MM, et al. Among authors: cook jm. Brain Res. 2008 May 7;1208:150-9. doi: 10.1016/j.brainres.2008.02.020. Epub 2008 Feb 19. Brain Res. 2008. PMID: 18394590 Free PMC article.

8

Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.

Harris D, Clayton T, Cook J, Sahbaie P, Halliwell RF, Furtmüller R, Huck S, Sieghart W, DeLorey TM. Harris D, et al. Among authors: cook j. J Med Chem. 2008 Jul 10;51(13):3788-803. doi: 10.1021/jm701433b. Epub 2008 Jun 7. J Med Chem. 2008. PMID: 18537233

9

A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis.

Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, Weed MR, Cook JM. Han D, et al. Bioorg Med Chem. 2008 Oct 1;16(19):8853-62. doi: 10.1016/j.bmc.2008.08.072. Epub 2008 Sep 2. Bioorg Med Chem. 2008. PMID: 18790643 Free PMC article.

10

Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models.

Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM. Rivas FM, et al. Among authors: cook jm. J Med Chem. 2009 Apr 9;52(7):1795-8. doi: 10.1021/jm801652d. J Med Chem. 2009. PMID: 19275170 Free PMC article.

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