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Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.
McDonald IM, Grant GD, East MP, Gilbert TSK, Wilkerson EM, Goldfarb D, Beri J, Herring LE, Vaziri C, Cook JG, Emanuele MJ, Graves LM. McDonald IM, et al. Among authors: cook jg. J Biol Chem. 2020 Feb 21;295(8):2359-2374. doi: 10.1074/jbc.RA119.011083. Epub 2020 Jan 2. J Biol Chem. 2020. PMID: 31896573 Free PMC article.
Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.
Hall JR, Lee HO, Bunker BD, Dorn ES, Rogers GC, Duronio RJ, Cook JG. Hall JR, et al. Among authors: cook jg. J Biol Chem. 2008 Sep 12;283(37):25356-25363. doi: 10.1074/jbc.M802667200. Epub 2008 Jul 10. J Biol Chem. 2008. PMID: 18617514 Free PMC article.
Sequential replication-coupled destruction at G1/S ensures genome stability.
Coleman KE, Grant GD, Haggerty RA, Brantley K, Shibata E, Workman BD, Dutta A, Varma D, Purvis JE, Cook JG. Coleman KE, et al. Among authors: cook jg. Genes Dev. 2015 Aug 15;29(16):1734-46. doi: 10.1101/gad.263731.115. Epub 2015 Aug 13. Genes Dev. 2015. PMID: 26272819 Free PMC article.
The Temporal Regulation of S Phase Proteins During G1.
Grant GD, Cook JG. Grant GD, et al. Among authors: cook jg. Adv Exp Med Biol. 2017;1042:335-369. doi: 10.1007/978-981-10-6955-0_16. Adv Exp Med Biol. 2017. PMID: 29357066 Free PMC article. Review.
121 results