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OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth.
Towner RA, Smith N, Saunders D, Brown CA, Cai X, Ziegler J, Mallory S, Dozmorov MG, Coutinho De Souza P, Wiley G, Kim K, Kang S, Kong DS, Kim YT, Fung KM, Wren JD, Battiste J. Towner RA, et al. Among authors: coutinho de souza p. Transl Oncol. 2019 Feb;12(2):320-335. doi: 10.1016/j.tranon.2018.10.002. Epub 2018 Nov 20. Transl Oncol. 2019. PMID: 30468988 Free PMC article.
OKN-007 decreases free radical levels in a preclinical F98 rat glioma model.
Coutinho de Souza P, Smith N, Atolagbe O, Ziegler J, Njoku C, Lerner M, Ehrenshaft M, Mason RP, Meek B, Plafker SM, Saunders D, Mamedova N, Towner RA. Coutinho de Souza P, et al. Free Radic Biol Med. 2015 Oct;87:157-68. doi: 10.1016/j.freeradbiomed.2015.06.026. Epub 2015 Jun 26. Free Radic Biol Med. 2015. PMID: 26119786 Free PMC article.
ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.
Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H, Dong J, Lerner M, Mian O, Tummala S, Battiste J, Fung KM, Wren JD, Towner RA. Ziegler J, et al. Among authors: coutinho de souza p. Neuro Oncol. 2017 Feb 1;19(2):175-185. doi: 10.1093/neuonc/now147. Neuro Oncol. 2017. PMID: 27416955 Free PMC article.
PFKFB3-mediated Pro-glycolytic Shift in Hepatocellular Carcinoma Proliferation.
Dou Q, Grant AK, Callahan C, Coutinho de Souza P, Mwin D, Booth AL, Nasser I, Moussa M, Ahmed M, Tsai LL. Dou Q, et al. Among authors: coutinho de souza p. Cell Mol Gastroenterol Hepatol. 2023;15(1):61-75. doi: 10.1016/j.jcmgh.2022.09.009. Epub 2022 Sep 24. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36162723 Free PMC article.
Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment.
Kurien BT, Harris VM, Quadri SM, Coutinho-de Souza P, Cavett J, Moyer A, Ittiq B, Metcalf A, Ramji HF, Truong D, Kumar R, Koelsch KA, Centola M, Payne A, Danda D, Scofield RH. Kurien BT, et al. Among authors: coutinho de souza p. Lupus Sci Med. 2015 Sep 8;2(1):e000114. doi: 10.1136/lupus-2015-000114. eCollection 2015. Lupus Sci Med. 2015. PMID: 26380101 Free PMC article.