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The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia.
Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macías D, Bargiela DM, Pietsch S, Gralla M, Evans CE, Kittipassorn T, Chey YCJ, Branco CM, Rundqvist H, Peet DJ, Johnson RS. Sim J, et al. Among authors: cowburn as. Cell Metab. 2018 Apr 3;27(4):898-913.e7. doi: 10.1016/j.cmet.2018.02.020. Cell Metab. 2018. PMID: 29617647 Free PMC article.
Epidermal deletion of HIF-2α stimulates wound closure.
Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS. Cowburn AS, et al. J Invest Dermatol. 2014 Mar;134(3):801-808. doi: 10.1038/jid.2013.395. Epub 2013 Sep 13. J Invest Dermatol. 2014. PMID: 24037341 Free PMC article.
HIF2α-arginase axis is essential for the development of pulmonary hypertension.
Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS. Cowburn AS, et al. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8801-6. doi: 10.1073/pnas.1602978113. Epub 2016 Jul 18. Proc Natl Acad Sci U S A. 2016. PMID: 27432976 Free PMC article.
HIF-2α is essential for carotid body development and function.
Macias D, Cowburn AS, Torres-Torrelo H, Ortega-Sáenz P, López-Barneo J, Johnson RS. Macias D, et al. Among authors: cowburn as. Elife. 2018 Apr 19;7:e34681. doi: 10.7554/eLife.34681. Elife. 2018. PMID: 29671738 Free PMC article.
Cutaneous exposure to hypoxia does not affect skin perfusion in humans.
Siebenmann C, Keramidas ME, Rundqvist H, Mijwel S, Cowburn AS, Johnson RS, Eiken O. Siebenmann C, et al. Among authors: cowburn as. Acta Physiol (Oxf). 2017 Jul;220(3):361-369. doi: 10.1111/apha.12825. Epub 2016 Nov 30. Acta Physiol (Oxf). 2017. PMID: 27809413 Free PMC article.
HIF isoforms in the skin differentially regulate systemic arterial pressure.
Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS. Cowburn AS, et al. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17570-5. doi: 10.1073/pnas.1306942110. Epub 2013 Oct 7. Proc Natl Acad Sci U S A. 2013. PMID: 24101470 Free PMC article.
51 results