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Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Jazebi H, Cunninghame Graham DS, Grandits ME, Nazmul-Hossain AN, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJ, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Rönnblom L, Nordmark G, Ng WF; UK Primary Sjögren's Syndrome Registry; Mariette X, Anaya JM, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Sivils KL. Lessard CJ, et al. Among authors: cunninghame graham ds. Nat Genet. 2013 Nov;45(11):1284-92. doi: 10.1038/ng.2792. Epub 2013 Oct 6. Nat Genet. 2013. PMID: 24097067 Free PMC article.
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
Graham RR, Kyogoku C, Sigurdsson S, Vlasova IA, Davies LR, Baechler EC, Plenge RM, Koeuth T, Ortmann WA, Hom G, Bauer JW, Gillett C, Burtt N, Cunninghame Graham DS, Onofrio R, Petri M, Gunnarsson I, Svenungsson E, Rönnblom L, Nordmark G, Gregersen PK, Moser K, Gaffney PM, Criswell LA, Vyse TJ, Syvänen AC, Bohjanen PR, Daly MJ, Behrens TW, Altshuler D. Graham RR, et al. Among authors: cunninghame graham ds. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6758-63. doi: 10.1073/pnas.0701266104. Epub 2007 Apr 5. Proc Natl Acad Sci U S A. 2007. PMID: 17412832 Free PMC article.
Dense mapping of IL18 shows no association in SLE.
Guerra SG, Morris DL, Gateva V, Graham RR, Vyse TJ, Cunninghame Graham DS. Guerra SG, et al. Among authors: cunninghame graham ds, graham rr. Hum Mol Genet. 2011 Mar 1;20(5):1026-33. doi: 10.1093/hmg/ddq536. Epub 2010 Dec 13. Hum Mol Genet. 2011. PMID: 21149337 Free PMC article.
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.
Cunninghame Graham DS, Morris DL, Bhangale TR, Criswell LA, Syvänen AC, Rönnblom L, Behrens TW, Graham RR, Vyse TJ. Cunninghame Graham DS, et al. Among authors: graham rr. PLoS Genet. 2011 Oct;7(10):e1002341. doi: 10.1371/journal.pgen.1002341. Epub 2011 Oct 27. PLoS Genet. 2011. PMID: 22046141 Free PMC article.
The genetics of lupus: a functional perspective.
Guerra SG, Vyse TJ, Cunninghame Graham DS. Guerra SG, et al. Among authors: cunninghame graham ds. Arthritis Res Ther. 2012 May 29;14(3):211. doi: 10.1186/ar3844. Arthritis Res Ther. 2012. PMID: 22640752 Free PMC article. Review.
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