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Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system.
Haynes MK, Strouse JJ, Waller A, Leitao A, Curpan RF, Bologa C, Oprea TI, Prossnitz ER, Edwards BS, Sklar LA, Thompson TA. Haynes MK, et al. Among authors: curpan rf. J Biomol Screen. 2009 Jul;14(6):596-609. doi: 10.1177/1087057109335671. Epub 2009 May 21. J Biomol Screen. 2009. PMID: 19470718 Free PMC article.
Activation of Rho Family GTPases by Small Molecules.
Palsuledesai CC, Surviladze Z, Waller A, Miscioscia TF, Guo Y, Wu Y, Strouse J, Romero E, Salas VM, Curpan R, Young S, Carter M, Foutz T, Galochkina Z, Ames H, Haynes MK, Edwards BS, Nicolotti O, Luo L, Ursu O, Bologa CG, Oprea TI, Wandinger-Ness A, Sklar LA. Palsuledesai CC, et al. ACS Chem Biol. 2018 Jun 15;13(6):1514-1524. doi: 10.1021/acschembio.8b00038. Epub 2018 May 24. ACS Chem Biol. 2018. PMID: 29746086 Free PMC article.
A crowdsourcing evaluation of the NIH chemical probes.
Oprea TI, Bologa CG, Boyer S, Curpan RF, Glen RC, Hopkins AL, Lipinski CA, Marshall GR, Martin YC, Ostopovici-Halip L, Rishton G, Ursu O, Vaz RJ, Waller C, Waldmann H, Sklar LA. Oprea TI, et al. Among authors: curpan rf. Nat Chem Biol. 2009 Jul;5(7):441-7. doi: 10.1038/nchembio0709-441. Nat Chem Biol. 2009. PMID: 19536101 Free PMC article.
Novel drug targets in 2019.
Avram S, Halip L, Curpan R, Oprea TI. Avram S, et al. Nat Rev Drug Discov. 2020 May;19(5):300. doi: 10.1038/d41573-020-00052-w. Nat Rev Drug Discov. 2020. PMID: 32273590 No abstract available.
Off-Patent Drug Repositioning.
Avram S, Curpan R, Halip L, Bora A, Oprea TI. Avram S, et al. J Chem Inf Model. 2020 Dec 28;60(12):5746-5753. doi: 10.1021/acs.jcim.0c00826. Epub 2020 Sep 15. J Chem Inf Model. 2020. PMID: 32877182
DrugCentral 2021 supports drug discovery and repositioning.
Avram S, Bologa CG, Holmes J, Bocci G, Wilson TB, Nguyen DT, Curpan R, Halip L, Bora A, Yang JJ, Knockel J, Sirimulla S, Ursu O, Oprea TI. Avram S, et al. Nucleic Acids Res. 2021 Jan 8;49(D1):D1160-D1169. doi: 10.1093/nar/gkaa997. Nucleic Acids Res. 2021. PMID: 33151287 Free PMC article.
32 results