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A randomized phase-II study of BB-10010 (macrophage inflammatory protein- 1alpha) in patients with advanced breast cancer receiving 5-fluorouracil, adriamycin, and cyclophosphamide chemotherapy.
Clemons MJ, Marshall E, Dürig J, Watanabe K, Howell A, Miles D, Earl H, Kiernan J, Griffiths A, Towlson K, DeTakats P, Testa NG, Dougal M, Hunter MG, Wood LM, Czaplewski LG, Millar A, Dexter TM, Lord BI. Clemons MJ, et al. Among authors: czaplewski lg. Blood. 1998 Sep 1;92(5):1532-40. Blood. 1998. PMID: 9716580 Free article. Clinical Trial.
Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants.
Czaplewski LG, McKeating J, Craven CJ, Higgins LD, Appay V, Brown A, Dudgeon T, Howard LA, Meyers T, Owen J, Palan SR, Tan P, Wilson G, Woods NR, Heyworth CM, Lord BI, Brotherton D, Christison R, Craig S, Cribbes S, Edwards RM, Evans SJ, Gilbert R, Morgan P, Randle E, Schofield N, Varley PG, Fisher J, Waltho JP, Hunter MG. Czaplewski LG, et al. J Biol Chem. 1999 Jun 4;274(23):16077-84. doi: 10.1074/jbc.274.23.16077. J Biol Chem. 1999. PMID: 10347159 Free article.
Clinical effects of human macrophage inflammatory protein-1 alpha MIP-1 alpha (LD78) administration to humans: a phase I study in cancer patients and normal healthy volunteers with the genetically engineered variant, BB-10010.
Marshall E, Howell AH, Powles R, Hunter MG, Edwards M, Wood LM, Czaplewski L, Puttick R, Warrington S, Boyce M, Testa N, Dexter TM, Lord BI, Millar A. Marshall E, et al. Eur J Cancer. 1998 Jun;34(7):1023-9. doi: 10.1016/s0959-8049(97)10141-1. Eur J Cancer. 1998. PMID: 9849450 Clinical Trial.
Assays for macrophage inflammatory proteins.
Buckle AM, Craig S, Czaplewski LG. Buckle AM, et al. Among authors: czaplewski lg. Methods Enzymol. 1997;287:127-48. doi: 10.1016/s0076-6879(97)87011-5. Methods Enzymol. 1997. PMID: 9330319 No abstract available.
43 results