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Autocrine vitamin D signaling switches off pro-inflammatory programs of T(H)1 cells.
Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova-Lamperti E, Kumar D, Zhang Z, Teague H, West EE, Vannella KM, Ramos-Benitez MJ, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz DM, Portilla D, Chertow DS, John S, Lavender P, Kemper C, Lombardi G, Mehta NN, Cooper N, Lionakis MS, Laurence A, Kazemian M, Afzali B. Chauss D, et al. Nat Immunol. 2022 Jan;23(1):62-74. doi: 10.1038/s41590-021-01080-3. Epub 2021 Nov 11. Nat Immunol. 2022. PMID: 34764490 Free PMC article.
Here we show that complement triggers contraction of T(H)1 responses by inducing intrinsic expression of the vitamin D (VitD) receptor and the VitD-activating enzyme CYP27B1, permitting T cells to both activate and respond to VitD. ...
Here we show that complement triggers contraction of T(H)1 responses by inducing intrinsic expression of the vitamin D (VitD) recepto …
1,25-Dihydroxyvitamin D3 suppresses CD4+ T-cell effector functionality by inhibition of glycolysis.
Bishop EL, Gudgeon NH, Mackie GM, Chauss D, Roberts J, Tennant DA, Maslowski KM, Afzali B, Hewison M, Dimeloe S. Bishop EL, et al. Among authors: chauss d. Immunology. 2022 Jul;166(3):299-309. doi: 10.1111/imm.13472. Epub 2022 Mar 28. Immunology. 2022. PMID: 35322416 Free PMC article.
In CD4(+) T helper cells, the active form of vitamin D(3) , 1,25-dihydroxyvitamin D(3) (1,25D) suppresses production of inflammatory cytokines, including interferon-gamma (IFN-gamma), but the mechanisms for this are not yet fully defined. ...Finally, we demonstrate …
In CD4(+) T helper cells, the active form of vitamin D(3) , 1,25-dihydroxyvitamin D(3) (1,25D) suppresses production of inflam …
An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19.
McGregor R, Chauss D, Freiwald T, Yan B, Wang L, Nova-Lamperti E, Zhang Z, Teague H, West EE, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz D, Portilla D, John S, Lavender P, Lionakis MS, Mehta NN, Kemper C, Cooper N, Lombardi G, Laurence A, Kazemian M, Afzali B. McGregor R, et al. Among authors: chauss d. bioRxiv [Preprint]. 2020 Jul 19:2020.07.18.210161. doi: 10.1101/2020.07.18.210161. bioRxiv. 2020. PMID: 32743590 Free PMC article. Preprint.
Here, we show that complement triggers contraction of IFN-gamma producing CD4 (+) T helper (Th) 1 cell responses by inducing expression of the vitamin D (VitD) receptor (VDR) and CYP27B1, the enzyme that activates VitD, permitting T cells to both activate and respond to Vi …
Here, we show that complement triggers contraction of IFN-gamma producing CD4 (+) T helper (Th) 1 cell responses by inducing expression of t …