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RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.
Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M. Sager HB, et al. Among authors: dahlman je. Sci Transl Med. 2016 Jun 8;8(342):342ra80. doi: 10.1126/scitranslmed.aaf1435. Sci Transl Med. 2016. PMID: 27280687 Free PMC article.
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery.
Hatit MZC, Dobrowolski CN, Lokugamage MP, Loughrey D, Ni H, Zurla C, Da Silva Sanchez AJ, Radmand A, Huayamares SG, Zenhausern R, Paunovska K, Peck HE, Kim J, Sato M, Feldman JI, Rivera MA, Cristian A, Kim Y, Santangelo PJ, Dahlman JE. Hatit MZC, et al. Among authors: dahlman je. Nat Chem. 2023 Apr;15(4):508-515. doi: 10.1038/s41557-023-01138-9. Epub 2023 Mar 2. Nat Chem. 2023. PMID: 36864143
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo.
Huayamares SG, Lokugamage MP, Rab R, Da Silva Sanchez AJ, Kim H, Radmand A, Loughrey D, Lian L, Hou Y, Achyut BR, Ehrhardt A, Hong JS, Sago CD, Paunovska K, Echeverri ES, Vanover D, Santangelo PJ, Sorscher EJ, Dahlman JE. Huayamares SG, et al. Among authors: dahlman je. J Control Release. 2023 May;357:394-403. doi: 10.1016/j.jconrel.2023.04.005. Epub 2023 Apr 12. J Control Release. 2023. PMID: 37028451 Free PMC article.
Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery.
Da Silva Sanchez AJ, Zhao K, Huayamares SG, Hatit MZC, Lokugamage MP, Loughrey D, Dobrowolski C, Wang S, Kim H, Paunovska K, Kuzminich Y, Dahlman JE. Da Silva Sanchez AJ, et al. Among authors: dahlman je. J Control Release. 2023 Jan;353:270-277. doi: 10.1016/j.jconrel.2022.11.037. Epub 2022 Nov 30. J Control Release. 2023. PMID: 36423872 Free PMC article.
Alkane-modified short polyethyleneimine for siRNA delivery.
Schroeder A, Dahlman JE, Sahay G, Love KT, Jiang S, Eltoukhy AA, Levins CG, Wang Y, Anderson DG. Schroeder A, et al. Among authors: dahlman je. J Control Release. 2012 Jun 10;160(2):172-6. doi: 10.1016/j.jconrel.2011.11.030. Epub 2011 Dec 2. J Control Release. 2012. PMID: 22155553 Free PMC article.
Treating metastatic cancer with nanotechnology.
Schroeder A, Heller DA, Winslow MM, Dahlman JE, Pratt GW, Langer R, Jacks T, Anderson DG. Schroeder A, et al. Among authors: dahlman je. Nat Rev Cancer. 2011 Dec 23;12(1):39-50. doi: 10.1038/nrc3180. Nat Rev Cancer. 2011. PMID: 22193407 Review.
Silencing or stimulation? siRNA delivery and the immune system.
Whitehead KA, Dahlman JE, Langer RS, Anderson DG. Whitehead KA, et al. Among authors: dahlman je. Annu Rev Chem Biomol Eng. 2011;2:77-96. doi: 10.1146/annurev-chembioeng-061010-114133. Annu Rev Chem Biomol Eng. 2011. PMID: 22432611 Review.
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