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Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.
Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Pérez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA. Hehl LA, et al. Among authors: horn ghetko d. Nat Chem Biol. 2024 Feb;20(2):190-200. doi: 10.1038/s41589-023-01414-2. Epub 2023 Aug 24. Nat Chem Biol. 2024. PMID: 37620400 Free PMC article.
K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution.
Suryo Rahmanto A, Blum CJ, Scalera C, Heidelberger JB, Mesitov M, Horn-Ghetko D, Gräf JF, Mikicic I, Hobrecht R, Orekhova A, Ostermaier M, Ebersberger S, Möckel MM, Krapoth N, Da Silva Fernandes N, Mizi A, Zhu Y, Chen JX, Choudhary C, Papantonis A, Ulrich HD, Schulman BA, König J, Beli P. Suryo Rahmanto A, et al. Among authors: horn ghetko d. Mol Cell. 2023 Dec 7;83(23):4272-4289.e10. doi: 10.1016/j.molcel.2023.10.011. Epub 2023 Nov 10. Mol Cell. 2023. PMID: 37951215 Free article.
A Pro-Fluorescent Ubiquitin-Based Probe to Monitor Cysteine-Based E3 Ligase Activity.
Pérez Berrocal DA, Vishwanatha TM, Horn-Ghetko D, Botsch JJ, Hehl LA, Kostrhon S, Misra M, Ðikić I, Geurink PP, van Dam H, Schulman BA, Mulder MPC. Pérez Berrocal DA, et al. Among authors: horn ghetko d. Angew Chem Int Ed Engl. 2023 Aug 7;62(32):e202303319. doi: 10.1002/anie.202303319. Epub 2023 Jun 27. Angew Chem Int Ed Engl. 2023. PMID: 37272691
New classes of E3 ligases illuminated by chemical probes.
Horn-Ghetko D, Schulman BA. Horn-Ghetko D, et al. Curr Opin Struct Biol. 2022 Apr;73:102341. doi: 10.1016/j.sbi.2022.102341. Epub 2022 Feb 25. Curr Opin Struct Biol. 2022. PMID: 35228042 Free article. Review.