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Page 1
Development of a chemical probe against NUDT15.
Nat Chem Biol. 2020 Oct;16(10):1120-1128. doi: 10.1038/s41589-020-0592-z. Epub 2020 Jul 20.
Nat Chem Biol. 2020.
PMID: 32690945
Free PMC article.
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Zhang SM, Rehling D, Jemth AS, Throup A, Landázuri N, Almlöf I, Göttmann M, Valerie NCK, Borhade SR, Wakchaure P, Page BDG, Desroses M, Homan EJ, Scobie M, Rudd SG, Berglund UW, Söderberg-Nauclér C, Stenmark P, Helleday T.
Zhang SM, et al. Among authors: rehling d.
Cell Chem Biol. 2021 Dec 16;28(12):1693-1702.e6. doi: 10.1016/j.chembiol.2021.06.001. Epub 2021 Jun 29.
Cell Chem Biol. 2021.
PMID: 34192523
Free article.
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NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir.
Nishii R, Mizuno T, Rehling D, Smith C, Clark BL, Zhao X, Brown SA, Smart B, Moriyama T, Yamada Y, Ichinohe T, Onizuka M, Atsuta Y, Yang L, Yang W, Thomas PG, Stenmark P, Kato M, Yang JJ.
Nishii R, et al. Among authors: rehling d.
Nat Commun. 2021 Jul 7;12(1):4181. doi: 10.1038/s41467-021-24509-7.
Nat Commun. 2021.
PMID: 34234136
Free PMC article.
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Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Rehling D, Scaletti ER, Rozman Grinberg I, Lundin D, Sahlin M, Hofer A, Sjöberg BM, Stenmark P.
Rehling D, et al.
Biochemistry. 2022 Jan 18;61(2):92-106. doi: 10.1021/acs.biochem.1c00503. Epub 2021 Dec 23.
Biochemistry. 2022.
PMID: 34941255
Free PMC article.
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NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Valerie NC, Hagenkort A, Page BD, Masuyer G, Rehling D, Carter M, Bevc L, Herr P, Homan E, Sheppard NG, Stenmark P, Jemth AS, Helleday T.
Valerie NC, et al. Among authors: rehling d.
Cancer Res. 2016 Sep 15;76(18):5501-11. doi: 10.1158/0008-5472.CAN-16-0584. Epub 2016 Aug 16.
Cancer Res. 2016.
PMID: 27530327
Free PMC article.
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Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Rehling D, Zhang SM, Jemth AS, Koolmeister T, Throup A, Wallner O, Scaletti E, Moriyama T, Nishii R, Davies J, Desroses M, Rudd SG, Scobie M, Homan E, Berglund UW, Yang JJ, Helleday T, Stenmark P.
Rehling D, et al.
J Biol Chem. 2021 Jan-Jun;296:100568. doi: 10.1016/j.jbc.2021.100568. Epub 2021 Mar 19.
J Biol Chem. 2021.
PMID: 33753169
Free PMC article.
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