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2022 5
2023 3
2024 0

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Page 1
IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer.
Blomberg OS, Spagnuolo L, Garner H, Voorwerk L, Isaeva OI, van Dyk E, Bakker N, Chalabi M, Klaver C, Duijst M, Kersten K, Brüggemann M, Pastoors D, Hau CS, Vrijland K, Raeven EAM, Kaldenbach D, Kos K, Afonina IS, Kaptein P, Hoes L, Theelen WSME, Baas P, Voest EE, Beyaert R, Thommen DS, Wessels LFA, de Visser KE, Kok M. Blomberg OS, et al. Among authors: kaldenbach d. Cancer Cell. 2023 Jan 9;41(1):106-123.e10. doi: 10.1016/j.ccell.2022.11.014. Epub 2022 Dec 15. Cancer Cell. 2023. PMID: 36525971 Free article.
Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors.
Blomberg OS, Kos K, Spagnuolo L, Isaeva OI, Garner H, Wellenstein MD, Bakker N, Duits DEM, Kersten K, Klarenbeek S, Hau CS, Kaldenbach D, Raeven EAM, Vrijland K, Kok M, de Visser KE. Blomberg OS, et al. Among authors: kaldenbach d. Oncoimmunology. 2023 Apr 13;12(1):2201147. doi: 10.1080/2162402X.2023.2201147. eCollection 2023. Oncoimmunology. 2023. PMID: 37089449 Free PMC article.
Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding.
Bruekner SR, Pieters W, Fish A, Liaci AM, Scheffers S, Rayner E, Kaldenbach D, Drost L, Dekker M, van Hees-Stuivenberg S, Delzenne-Goette E, de Konink C, Houlleberghs H, Dubbink HJ, AlSaegh A, de Wind N, Förster F, Te Riele H, Sixma TK. Bruekner SR, et al. Among authors: kaldenbach d. Nucleic Acids Res. 2023 Feb 22;51(3):1173-1188. doi: 10.1093/nar/gkad015. Nucleic Acids Res. 2023. PMID: 36715327 Free PMC article.
Pro-mutagenic effects of the gut microbiota in a Lynch syndrome mouse model.
Pieters W, Hugenholtz F, Kos K, Cammeraat M, Moliej TC, Kaldenbach D, Klarenbeek S, Davids M, Drost L, de Konink C, Delzenne-Goette E, de Visser KE, Te Riele H. Pieters W, et al. Among authors: kaldenbach d. Gut Microbes. 2022 Jan-Dec;14(1):2035660. doi: 10.1080/19490976.2022.2035660. Gut Microbes. 2022. PMID: 35188867 Free PMC article.
Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche.
Kos K, Aslam MA, van de Ven R, Wellenstein MD, Pieters W, van Weverwijk A, Duits DEM, van Pul K, Hau CS, Vrijland K, Kaldenbach D, Raeven EAM, Quezada SA, Beyaert R, Jacobs H, de Gruijl TD, de Visser KE. Kos K, et al. Among authors: kaldenbach d. Cell Rep. 2022 Mar 1;38(9):110447. doi: 10.1016/j.celrep.2022.110447. Cell Rep. 2022. PMID: 35235800 Free article.
Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling.
Kos K, Salvagno C, Wellenstein MD, Aslam MA, Meijer DA, Hau CS, Vrijland K, Kaldenbach D, Raeven EAM, Schmittnaegel M, Ries CH, de Visser KE. Kos K, et al. Among authors: kaldenbach d. Oncoimmunology. 2022 Apr 15;11(1):2063225. doi: 10.1080/2162402X.2022.2063225. eCollection 2022. Oncoimmunology. 2022. PMID: 35481289 Free PMC article.