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MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors.
Kim H, Lebeau B, Papadopoli D, Jovanovic P, Russo M, Avizonis D, Morita M, Afzali F, Ursini-Siegel J, Postovit LM, Witcher M, Topisirovic I. Kim H, et al. Among authors: papadopoli d. iScience. 2024 Feb 12;27(3):109188. doi: 10.1016/j.isci.2024.109188. eCollection 2024 Mar 15. iScience. 2024. PMID: 38433910 Free PMC article.
The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.
Findlay S, Nair R, Merrill RA, Kaiser Z, Cajelot A, Aryanpour Z, Heath J, St-Louis C, Papadopoli D, Topisirovic I, St-Pierre J, Sebag M, Kesarwala AH, Hulea L, Taylor EB, Shanmugam M, Orthwein A. Findlay S, et al. Among authors: papadopoli d. Blood Adv. 2023 Jul 25;7(14):3485-3500. doi: 10.1182/bloodadvances.2022008345. Blood Adv. 2023. PMID: 36920785 Free PMC article.
Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids.
Abdullah MO, Zeng RX, Margerum CL, Papadopoli D, Monnin C, Punter KB, Chu C, Al-Rofaidi M, Al-Tannak NF, Berardi D, Rattray Z, Rattray NJW, Abraham SA, Eskelinen EL, Watson DG, Avizonis D, Topisirovic I, Chan EYW. Abdullah MO, et al. Among authors: papadopoli d. Cell Rep. 2022 Aug 16;40(7):111198. doi: 10.1016/j.celrep.2022.111198. Cell Rep. 2022. PMID: 35977476 Free article.
Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells.
Uchenunu O, Zhdanov AV, Hutton P, Jovanovic P, Wang Y, Andreev DE, Hulea L, Papadopoli DJ, Avizonis D, Baranov PV, Pollak MN, Papkovsky DB, Topisirovic I. Uchenunu O, et al. Among authors: papadopoli dj. FEBS Open Bio. 2022 May;12(5):959-982. doi: 10.1002/2211-5463.13398. Epub 2022 Apr 1. FEBS Open Bio. 2022. PMID: 35302710 Free PMC article.
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma.
Smith LK, Parmenter T, Kleinschmidt M, Kusnadi EP, Kang J, Martin CA, Lau P, Patel R, Lorent J, Papadopoli D, Trigos A, Ward T, Rao AD, Lelliott EJ, Sheppard KE, Goode D, Hicks RJ, Tiganis T, Simpson KJ, Larsson O, Blythe B, Cullinane C, Wickramasinghe VO, Pearson RB, McArthur GA. Smith LK, et al. Among authors: papadopoli d. Nat Commun. 2022 Mar 1;13(1):1100. doi: 10.1038/s41467-022-28705-x. Nat Commun. 2022. PMID: 35232962 Free PMC article.
A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Igelmann S, Lessard F, Uchenunu O, Bouchard J, Fernandez-Ruiz A, Rowell MC, Lopes-Paciencia S, Papadopoli D, Fouillen A, Ponce KJ, Huot G, Mignacca L, Benfdil M, Kalegari P, Wahba HM, Pencik J, Vuong N, Quenneville J, Guillon J, Bourdeau V, Hulea L, Gagnon E, Kenner L, Moriggl R, Nanci A, Pollak MN, Omichinski JG, Topisirovic I, Ferbeyre G. Igelmann S, et al. Among authors: papadopoli d. Mol Cell. 2021 Sep 16;81(18):3848-3865.e19. doi: 10.1016/j.molcel.2021.08.028. Mol Cell. 2021. PMID: 34547241 Free article.
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK.
Tan C, Ginzberg MB, Webster R, Iyengar S, Liu S, Papadopoli D, Concannon J, Wang Y, Auld DS, Jenkins JL, Rost H, Topisirovic I, Hilfinger A, Derry WB, Patel N, Kafri R. Tan C, et al. Among authors: papadopoli d. Dev Cell. 2021 Jun 21;56(12):1756-1769.e7. doi: 10.1016/j.devcel.2021.04.030. Epub 2021 May 21. Dev Cell. 2021. PMID: 34022133 Free article.
The role of GSK3 in metabolic pathway perturbations in cancer.
Papadopoli D, Pollak M, Topisirovic I. Papadopoli D, et al. Biochim Biophys Acta Mol Cell Res. 2021 Jul;1868(8):119059. doi: 10.1016/j.bbamcr.2021.119059. Epub 2021 May 12. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33989699 Free article. Review.
Cancer Plasticity: The Role of mRNA Translation.
Lee LJ, Papadopoli D, Jewer M, Del Rincon S, Topisirovic I, Lawrence MG, Postovit LM. Lee LJ, et al. Among authors: papadopoli d. Trends Cancer. 2021 Feb;7(2):134-145. doi: 10.1016/j.trecan.2020.09.005. Epub 2020 Oct 13. Trends Cancer. 2021. PMID: 33067172 Free PMC article. Review.
18 results