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Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.
Leroy J, Richards MW, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, Dolphin AC. Leroy J, et al. Among authors: davies a. J Neurosci. 2005 Jul 27;25(30):6984-96. doi: 10.1523/JNEUROSCI.1137-05.2005. J Neurosci. 2005. PMID: 16049174 Free PMC article.
The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels.
Cantí C, Nieto-Rostro M, Foucault I, Heblich F, Wratten J, Richards MW, Hendrich J, Douglas L, Page KM, Davies A, Dolphin AC. Cantí C, et al. Among authors: davies a. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11230-5. doi: 10.1073/pnas.0504183102. Epub 2005 Aug 1. Proc Natl Acad Sci U S A. 2005. PMID: 16061813 Free PMC article.
The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function.
Brodbeck J, Davies A, Courtney JM, Meir A, Balaguero N, Canti C, Moss FJ, Page KM, Pratt WS, Hunt SP, Barclay J, Rees M, Dolphin AC. Brodbeck J, et al. Among authors: davies a. J Biol Chem. 2002 Mar 8;277(10):7684-93. doi: 10.1074/jbc.M109404200. Epub 2001 Dec 26. J Biol Chem. 2002. PMID: 11756448 Free article.
4,384 results