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From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors.
Gardner CR, Davies KA, Zhang Y, Brzozowski M, Czabotar PE, Murphy JM, Lessene G. Gardner CR, et al. Among authors: davies ka. J Med Chem. 2023 Feb 23;66(4):2361-2385. doi: 10.1021/acs.jmedchem.2c01621. Epub 2023 Feb 13. J Med Chem. 2023. PMID: 36781172 Free PMC article. Review.
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies.
Petrie EJ, Birkinshaw RW, Koide A, Denbaum E, Hildebrand JM, Garnish SE, Davies KA, Sandow JJ, Samson AL, Gavin X, Fitzgibbon C, Young SN, Hennessy PJ, Smith PPC, Webb AI, Czabotar PE, Koide S, Murphy JM. Petrie EJ, et al. Among authors: davies ka. Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8468-8475. doi: 10.1073/pnas.1919960117. Epub 2020 Mar 31. Proc Natl Acad Sci U S A. 2020. PMID: 32234780 Free PMC article.
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.
Samson AL, Zhang Y, Geoghegan ND, Gavin XJ, Davies KA, Mlodzianoski MJ, Whitehead LW, Frank D, Garnish SE, Fitzgibbon C, Hempel A, Young SN, Jacobsen AV, Cawthorne W, Petrie EJ, Faux MC, Shield-Artin K, Lalaoui N, Hildebrand JM, Silke J, Rogers KL, Lessene G, Hawkins ED, Murphy JM. Samson AL, et al. Among authors: davies ka. Nat Commun. 2020 Jun 19;11(1):3151. doi: 10.1038/s41467-020-16887-1. Nat Commun. 2020. PMID: 32561730 Free PMC article.
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL.
Sethi A, Horne CR, Fitzgibbon C, Wilde K, Davies KA, Garnish SE, Jacobsen AV, Samson AL, Hildebrand JM, Wardak A, Czabotar PE, Petrie EJ, Gooley PR, Murphy JM. Sethi A, et al. Among authors: davies ka. Cell Death Differ. 2022 Sep;29(9):1804-1815. doi: 10.1038/s41418-022-00965-6. Epub 2022 Mar 9. Cell Death Differ. 2022. PMID: 35264780 Free PMC article.
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase.
Pierotti CL, Jacobsen AV, Grohmann C, Dempsey RK, Etemadi N, Hildebrand JM, Fitzgibbon C, Young SN, Davies KA, Kersten WJA, Silke J, Lowes KN, Jousset Sabroux H, Huang DCS, van Delft MF, Murphy JM, Lessene G. Pierotti CL, et al. Among authors: davies ka. Biochem J. 2023 May 15;480(9):665-684. doi: 10.1042/BCJ20230035. Biochem J. 2023. PMID: 37115711 Free PMC article.
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.
Meng Y, Garnish SE, Davies KA, Black KA, Leis AP, Horne CR, Hildebrand JM, Hoblos H, Fitzgibbon C, Young SN, Dite T, Dagley LF, Venkat A, Kannan N, Koide A, Koide S, Glukhova A, Czabotar PE, Murphy JM. Meng Y, et al. Among authors: davies ka. Nat Commun. 2023 Oct 26;14(1):6804. doi: 10.1038/s41467-023-42255-w. Nat Commun. 2023. PMID: 37884510 Free PMC article.
192 results