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Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY. Shiryaev SA, et al. Among authors: day r. J Biol Chem. 2007 Jul 20;282(29):20847-53. doi: 10.1074/jbc.M703847200. Epub 2007 May 30. J Biol Chem. 2007. PMID: 17537721 Free article.
Substrate cleavage analysis of furin and related proprotein convertases. A comparative study.
Remacle AG, Shiryaev SA, Oh ES, Cieplak P, Srinivasan A, Wei G, Liddington RC, Ratnikov BI, Parent A, Desjardins R, Day R, Smith JW, Lebl M, Strongin AY. Remacle AG, et al. Among authors: day r. J Biol Chem. 2008 Jul 25;283(30):20897-906. doi: 10.1074/jbc.M803762200. Epub 2008 May 27. J Biol Chem. 2008. PMID: 18505722 Free PMC article.
Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.
Remacle AG, Gawlik K, Golubkov VS, Cadwell GW, Liddington RC, Cieplak P, Millis SZ, Desjardins R, Routhier S, Yuan XW, Neugebauer WA, Day R, Strongin AY. Remacle AG, et al. Among authors: day r. Int J Biochem Cell Biol. 2010 Jun;42(6):987-95. doi: 10.1016/j.biocel.2010.02.013. Epub 2010 Mar 1. Int J Biochem Cell Biol. 2010. PMID: 20197107 Free PMC article.
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.
Levesque C, Fugère M, Kwiatkowska A, Couture F, Desjardins R, Routhier S, Moussette P, Prahl A, Lammek B, Appel JR, Houghten RA, D'Anjou F, Dory YL, Neugebauer W, Day R. Levesque C, et al. Among authors: day r. J Med Chem. 2012 Dec 13;55(23):10501-11. doi: 10.1021/jm3011178. Epub 2012 Nov 14. J Med Chem. 2012. PMID: 23126600 Free PMC article.
2,493 results