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Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells.
J Biol Chem. 2022 Jan;298(1):101477. doi: 10.1016/j.jbc.2021.101477. Epub 2021 Dec 10.
J Biol Chem. 2022.
PMID: 34896393
Free PMC article.
A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors.
Romero C, Lambert LJ, Sheffler DJ, De Backer LJS, Raveendra-Panickar D, Celeridad M, Grotegut S, Rodiles S, Holleran J, Sergienko E, Pasquale EB, Cosford NDP, Tautz L.
Romero C, et al. Among authors: de backer ljs.
J Biol Chem. 2020 Feb 28;295(9):2601-2613. doi: 10.1074/jbc.RA119.010838. Epub 2020 Jan 17.
J Biol Chem. 2020.
PMID: 31953320
Free PMC article.
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Detection of Cellular Target Engagement for Small-Molecule Modulators of Striatal-Enriched Protein Tyrosine Phosphatase (STEP).
Han YN, Lambert LJ, De Backer LJS, Wu J, Cosford NDP, Tautz L.
Han YN, et al. Among authors: de backer ljs.
Methods Mol Biol. 2023;2706:167-175. doi: 10.1007/978-1-0716-3397-7_12.
Methods Mol Biol. 2023.
PMID: 37558948
Free PMC article.
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