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The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.
De Palma AM, Heggermont W, Lanke K, Coutard B, Bergmann M, Monforte AM, Canard B, De Clercq E, Chimirri A, Pürstinger G, Rohayem J, van Kuppeveld F, Neyts J. De Palma AM, et al. Among authors: de clercq e. J Virol. 2008 May;82(10):4720-30. doi: 10.1128/JVI.01338-07. Epub 2008 Mar 12. J Virol. 2008. PMID: 18337578 Free PMC article.
Selective inhibitors of picornavirus replication.
De Palma AM, Vliegen I, De Clercq E, Neyts J. De Palma AM, et al. Among authors: de clercq e. Med Res Rev. 2008 Nov;28(6):823-84. doi: 10.1002/med.20125. Med Res Rev. 2008. PMID: 18381747 Review.
The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases.
Gruez A, Selisko B, Roberts M, Bricogne G, Bussetta C, Jabafi I, Coutard B, De Palma AM, Neyts J, Canard B. Gruez A, et al. Among authors: de palma am. J Virol. 2008 Oct;82(19):9577-90. doi: 10.1128/JVI.00631-08. Epub 2008 Jul 16. J Virol. 2008. PMID: 18632861 Free PMC article.
35 results