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PKD2/polycystin-2 induces autophagy by forming a complex with BECN1.
Peña-Oyarzun D, Rodriguez-Peña M, Burgos-Bravo F, Vergara A, Kretschmar C, Sotomayor-Flores C, Ramirez-Sarmiento CA, De Smedt H, Reyes M, Perez W, Torres VA, Morselli E, Altamirano F, Wilson CAM, Hill JA, Lavandero S, Criollo A. Peña-Oyarzun D, et al. Among authors: de smedt h. Autophagy. 2021 Jul;17(7):1714-1728. doi: 10.1080/15548627.2020.1782035. Epub 2020 Jun 30. Autophagy. 2021. PMID: 32543276 Free PMC article.
Polycystin-2-dependent control of cardiomyocyte autophagy.
Criollo A, Altamirano F, Pedrozo Z, Schiattarella GG, Li DL, Rivera-Mejías P, Sotomayor-Flores C, Parra V, Villalobos E, Battiprolu PK, Jiang N, May HI, Morselli E, Somlo S, de Smedt H, Gillette TG, Lavandero S, Hill JA. Criollo A, et al. Among authors: de smedt h. J Mol Cell Cardiol. 2018 May;118:110-121. doi: 10.1016/j.yjmcc.2018.03.002. Epub 2018 Mar 6. J Mol Cell Cardiol. 2018. PMID: 29518398
Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.
Sammels E, Devogelaere B, Mekahli D, Bultynck G, Missiaen L, Parys JB, Cai Y, Somlo S, De Smedt H. Sammels E, et al. Among authors: de smedt h. J Biol Chem. 2010 Jun 11;285(24):18794-805. doi: 10.1074/jbc.M109.090662. Epub 2010 Apr 7. J Biol Chem. 2010. PMID: 20375013 Free PMC article.
mTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling.
Decuypere JP, Kindt D, Luyten T, Welkenhuyzen K, Missiaen L, De Smedt H, Bultynck G, Parys JB. Decuypere JP, et al. Among authors: de smedt h. PLoS One. 2013;8(4):e61020. doi: 10.1371/journal.pone.0061020. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565295 Free PMC article.
Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.
Mekahli D, Decuypere JP, Sammels E, Welkenhuyzen K, Schoeber J, Audrezet MP, Corvelyn A, Dechênes G, Ong AC, Wilmer MJ, van den Heuvel L, Bultynck G, Parys JB, Missiaen L, Levtchenko E, De Smedt H. Mekahli D, et al. Among authors: de smedt h. Pflugers Arch. 2014 Aug;466(8):1591-604. doi: 10.1007/s00424-013-1394-x. Epub 2013 Nov 6. Pflugers Arch. 2014. PMID: 24193408
Polycystins and cellular Ca2+ signaling.
Mekahli D, Parys JB, Bultynck G, Missiaen L, De Smedt H. Mekahli D, et al. Among authors: de smedt h. Cell Mol Life Sci. 2013 Aug;70(15):2697-712. doi: 10.1007/s00018-012-1188-x. Epub 2012 Oct 18. Cell Mol Life Sci. 2013. PMID: 23076254 Free PMC article. Review.
242 results