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Medin co-aggregates with vascular amyloid-β in Alzheimer's disease.
Wagner J, Degenhardt K, Veit M, Louros N, Konstantoulea K, Skodras A, Wild K, Liu P, Obermüller U, Bansal V, Dalmia A, Häsler LM, Lambert M, De Vleeschouwer M, Davies HA, Madine J, Kronenberg-Versteeg D, Feederle R, Del Turco D, Nilsson KPR, Lashley T, Deller T, Gearing M, Walker LC, Heutink P, Rousseau F, Schymkowitz J, Jucker M, Neher JJ. Wagner J, et al. Among authors: de vleeschouwer m. Nature. 2022 Dec;612(7938):123-131. doi: 10.1038/s41586-022-05440-3. Epub 2022 Nov 16. Nature. 2022. PMID: 36385530 Free PMC article.
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
Pras A, Houben B, Aprile FA, Seinstra R, Gallardo R, Janssen L, Hogewerf W, Gallrein C, De Vleeschouwer M, Mata-Cabana A, Koopman M, Stroo E, de Vries M, Louise Edwards S, Kirstein J, Vendruscolo M, Falsone SF, Rousseau F, Schymkowitz J, Nollen EAA. Pras A, et al. Among authors: de vleeschouwer m. EMBO J. 2021 Nov 2;40(21):e107568. doi: 10.15252/embj.2020107568. Epub 2021 Oct 7. EMBO J. 2021. PMID: 34617299 Free PMC article.
Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure.
Konstantoulea K, Guerreiro P, Ramakers M, Louros N, Aubrey LD, Houben B, Michiels E, De Vleeschouwer M, Lampi Y, Ribeiro LF, de Wit J, Xue WF, Schymkowitz J, Rousseau F. Konstantoulea K, et al. Among authors: de vleeschouwer m. EMBO J. 2022 Dec 17;41(2):e108591. doi: 10.15252/embj.2021108591. Epub 2021 Nov 29. EMBO J. 2022. PMID: 34842295 Free PMC article.
Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding.
Khodaparast L, Khodaparast L, Wu G, Michiels E, Gallardo R, Houben B, Garcia T, De Vleeschouwer M, Ramakers M, Wilkinson H, Duran-Romaña R, Van Eldere J, Rousseau F, Schymkowitz J. Khodaparast L, et al. Among authors: de vleeschouwer m. Nat Commun. 2023 Sep 9;14(1):5571. doi: 10.1038/s41467-023-41191-z. Nat Commun. 2023. PMID: 37689716 Free PMC article.
27 results